dat.anand1999: Studies on the Effectiveness of Oral Anticoagulants in...

In metadat: Meta-Analysis Datasets

Studies on the Effectiveness of Oral Anticoagulants in Patients with Coronary Artery Disease

Description

Results from 34 trials examining the effectiveness of oral anticoagulants in patients with coronary artery disease.

Usage

dat.anand1999

Format

The data frame contains the following columns:

study	character	author(s) or trial name
year	numeric	publication year
intensity	character	intensity of anticoagulation (low, medium, or high)
asp.t	numeric	concomitant use of aspirin in the treatment group (0 = no, 1 = yes)
asp.c	numeric	concomitant use of aspirin in the control group (0 = no, 1 = yes)
ai	numeric	number of deaths in the treatment group
n1i	numeric	number of patients in the treatment group
ci	numeric	number of deaths in the control group
n2i	numeric	number of patients in the control group

Details

The dataset includes the results from 34 randomized clinical trials that examined the effectiveness of oral anticoagulants in patients with coronary artery disease. The results given here are focused on the total mortality in the treatment versus control groups.

Concepts

medicine, cardiology, odds ratios, Mantel-Haenszel method

Note

Strictly speaking, there are only 31 trials, since Breddin et al. (1980) and ATACS (1990) are multiarm trials.

According to a correction, dat.anand1999$ci[29] should be 1. But then dat.anand1999$ci[21] would also have to be 1 (if these data indeed refer to the same control group). This appears contradictory, so this correction was not made.

Author(s)

Wolfgang Viechtbauer, [e-mail], https://www.metafor-project.org

Source

Anand, S. S., & Yusuf, S. (1999). Oral anticoagulant therapy in patients with coronary artery disease: A meta-analysis. Journal of the American Medical Association, 282(21), 2058–2067. https://doi.org/10.1001/jama.282.21.2058

Examples

### copy data into 'dat' and examine data
dat <- dat.anand1999
dat

## Not run: 

### load metafor package
library(metafor)

### High-Intensity OA vs Control
rma.mh(measure="OR", ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat,
       subset=(intensity=="high" & asp.t==0 & asp.c==0), digits=2)

### High- or Moderate-Intensity OA vs Aspirin
rma.mh(measure="OR", ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat,
       subset=(intensity %in% c("high","moderate") & asp.t==0 & asp.c==1), digits=2)

### Moderate-Intensity OA vs Control
rma.mh(measure="OR", ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat,
       subset=(intensity=="moderate" & asp.t==0 & asp.c==0), digits=2)

### High- or Moderate-Intensity OA and Aspirin vs Aspirin
rma.mh(measure="OR", ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat,
       subset=(intensity %in% c("high","moderate") & asp.t==1 & asp.c==1), digits=2)

### Low-Intensity OA and Aspirin vs Aspirin
rma.mh(measure="OR", ai=ai, n1i=n1i, ci=ci, n2i=n2i, data=dat,
       subset=(intensity=="low" & asp.t==1 & asp.c==1), digits=2)


## End(Not run)

metadat documentation built on April 6, 2022, 5:08 p.m.