dat.thompson1999: Trials on Serum Cholesterin Concentration Lowering and Risk...

In metadat: Meta-Analysis Datasets

Trials on Serum Cholesterin Concentration Lowering and Risk of Ischaemic Heart Disease

Description

Results from 28 trials evaluating effect of serum cholesterin concentration lowering on risk of ischaemic heart disease

Usage

dat.thompson1999

Format

The data frame contains the following columns:

studyid	integer	study ID
ihd.cont	integer	number of ischaemic heart disease (control group)
noihd.cont	integer	number of non-events (control group)
ihd.exp	integer	number of ischaemic heart disease (treated group)
noihd.exp	integer	number of non-events (treated group)
OR	numeric	odds ratio
logOR	numeric	log odds ratio
varlogOR	numeric	variance of log odds ratio
cholr	numeric	cholesterol reduction (mmol/l)

Details

Thompson and Sharp (1999) compare several meta-regression approaches to explain heterogeneity in meta-analysis. The data set used is originally from Law et al. (1994), but with minor modifications.

Concepts

medicine, cardiology, odds ratios, meta-regression

Author(s)

Guido Schwarzer, [e-mail], https://github.com/guido-s/

Source

Thompson, S. G., & Sharp, S. J. (1999). Explaining heterogeneity in meta-analysis: A comparison of methods. Statistics in Medicine, 18(20), 2693–2708. ⁠https://doi.org/10.1002/(sici)1097-0258(19991030)18:20<2693::aid-sim235>3.0.co;2-v⁠

References

Law, M. R., Wald, N. J., & Thompson, S. G. (1994). By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? British Medical Journal, 308(6925), 367–372. ⁠https://doi.org/10.1136/bmj.308.6925.367⁠

Examples

### Show first five studies
head(dat.thompson1999, 5)

## Not run: 
### Load meta package
suppressPackageStartupMessages(library(meta))

### Conduct meta-analysis
m <- metabin(ihd.exp, ihd.exp + noihd.exp, ihd.cont, ihd.cont + noihd.cont,
  data = dat.thompson1999, sm = "OR", method = "Inverse")

### Thompson & Sharp (1999), Table III
### (1) None
metareg(m, cholr, method.tau = "FE")
### (3a) Additive (MM)
metareg(m, cholr, method.tau = "DL")

## End(Not run)

metadat documentation built on April 29, 2026, 5:10 p.m.