mrgsolve: Simulate from ODE-Based Population PK/PD and Systems Pharmacology Models

Facilitates simulation from hierarchical, ordinary differential equation (ODE) based models typically employed in drug development. A model specification file is created consisting of R and C++ code that is parsed, compiled, and dynamically loaded into the R session. Input data are passed in and simulated data are returned as R objects. A dosing event engine allows interventions (bolus and infusion) to be managed separately from the model code. Differential equations are solved with the 'DLSODA' routine in 'ODEPACK' (<https://computation.llnl.gov/casc/odepack/>).

Getting started

Package details

AuthorKyle T Baron [aut, cre], Alan C Hindmarsh [ctb], Linda R Petzold [ctb], Bill Gillespie [ctb], Charles Margossian [ctb], Devin Pastoor [ctb], Metrum Research Group LLC [cph]
MaintainerKyle T Baron <[email protected]>
LicenseGPL (>= 2)
Version0.8.12
URL https://github.com/metrumresearchgroup/mrgsolve
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("mrgsolve")

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mrgsolve documentation built on April 28, 2018, 1:04 a.m.