nlmixr2est: Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Getting started

Package details

AuthorMatthew Fidler [aut, cre] (ORCID: <https://orcid.org/0000-0001-8538-6691>), Wenping Wang [aut], Audrey Lavenu [ctb], Ben Goodrich [ctb], David Ardia [cph], Dirk Eddelbuettel [cph], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Hadley Wickham [ctb], Hajar Besbassi [ctb], Hidde van de Beek [ctb], Johannes Pfeifer [ctb], Justin Wilkins [aut] (ORCID: <https://orcid.org/0000-0002-7099-9396>), Katharine Mullen [cph], Mahmoud Abdelwahab [ctb], Marc Lavielle [ctb], Mason McComb [ctb] (ORCID: <https://orcid.org/0000-0001-9871-8616>), Mirjam Trame [ctb], Richard Hooijmaijers [aut], Rik Schoemaker [aut] (ORCID: <https://orcid.org/0000-0002-7538-3005>), Robert B. Schnabel [ctb], Robert Leary [ctb], Teun Post [ctb], Vipul Mann [aut], Yuan Xiong [aut]
MaintainerMatthew Fidler <matthew.fidler@gmail.com>
LicenseGPL (>= 3)
Version7.0.2
URL https://github.com/nlmixr2/nlmixr2est https://nlmixr2.github.io/nlmixr2est/
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("nlmixr2est")

Try the nlmixr2est package in your browser

Any scripts or data that you put into this service are public.

nlmixr2est documentation built on Aug. 5, 2026, 1:11 a.m.