dot-preProcessZeroTheta: Nudge exactly-zero theta initial estimates off zero (FOCEi...

In nlmixr2est: Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Nudge exactly-zero theta initial estimates off zero (FOCEi family)

Description

FOCEi scales a linear parameter by its native magnitude '|init|', which is '0' (no scale) when a population parameter is initialized at exactly '0' (the parameter then freezes). This hook moves every estimated, non-fixed 'theta' whose initial estimate is exactly '0' to '+zeroTheta' when that is within its bounds, otherwise '-zeroTheta'; if neither is within the bounds it errors. Only runs for the FOCEi family (a 'foceiControl'), and runs before '.preProcessBoundedTransform' so the nudged value is what gets transformed.

Usage

.preProcessZeroTheta(ui, est, data, control)

Arguments

ui	rxode2 ui model
est	estimation method (all methods are shown by 'nlmixr2AllEst()'). Methods can be added for other tools
data	nlmixr data
control	The estimation control object. These are expected to be different for each type of estimation method

Value

list with the ui (possibly modified)

Author(s)

Matthew L. Fidler

nlmixr2est documentation built on Aug. 5, 2026, 1:11 a.m.