dot-preProcessLinCmtOde: Translate a mixed 'linCmt()'/ODE model to all-ODEs

In nlmixr2est: Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Translate a mixed 'linCmt()'/ODE model to all-ODEs

Description

rxode2 requires the 'linCmt()' compartments to be the last states of the solve ('op$linOffset = neq - numLin - numLinSens'), so their compartment number is one past the ODE states. The FOCEi inner model adds an ODE state per eta, and the nlm family one per theta, which pushes depot/central past the compartment numbers the data was translated against ('.foceiPreProcessData()' uses the plain model). A dose then silently lands in a sensitivity state – every prediction comes back 0. Solving the linear part as ODEs removes the 'linCmt()' block, so the numbering agrees again. SAEM builds no sensitivity states and is left alone.

Usage

.preProcessLinCmtOde(ui, est, data, control)

Arguments

ui	rxode2 ui
est	estimation method (all methods are shown by 'nlmixr2AllEst()'). Methods can be added for other tools
data	nlmixr data
control	The estimation control object. These are expected to be different for each type of estimation method

Value

list with the translated ui, or 'NULL' when nothing to do

Author(s)

Matthew L. Fidler

nlmixr2est documentation built on Aug. 5, 2026, 1:11 a.m.