NEWS.md
In nlmixr2lib: A Model Library for 'nlmixr2'

nlmixr2lib

Version 0.3.0

Added ability to choose style type when modifying models. Currently supported styles are: "camel" for variablesLikeThis, "snake" for variables_like_this, "dot" for variables.like.this and "blank" for variableslikethis. This can be selected with setCombineType().
With the new combination style, you can change how eta variables are constructed with the option(nlmixr2lib.etaCombineType="camel") or whatever you wish it to the variable style to be.
Added new model building framework for building models
PK model building functions
- addTransit()/removeTransit() which were present before, but now modified and made a bit more robust, more closely matching literature method of transit compartments.
- addDepot()/removeDepot() which were present before, but modified to be a bit more robust.
- addWeibullAbs() which adds a Weibull absorption to a PK model
- convertMM() converts linear elimination to Michaelis-Menten elimination
- transPK() converts the cl style parameter transformations to various other PK transformations like k, aob, alpha, k12
PD model building functions
addIndirectLin() -- this adds an indirect effect model to a PK model that has a concentration Cc in the model. This purposely uses a simple linear effect of Cc*Ek or Cc*Ik so it will be easy to parse and turn into other functional forms (like Emax or Hill). If the PK model is not present it will use Cc as a covariate in a purely PD models.
addIndirect() -- this builds on addIndirectLin() and adds Emax or Hill models to a PK model. You can also set imax=1 or emax=1 to drop these parameters from being estimated in the model. Additionally hill=TRUE will add a Hill coefficient to the sigmoid model.
addEffectCmtLin() -- this adds an effect compartment based on the Cc in the model. The linear effect can be modified into other function forms.
addDirectLin() -- this adds a direct effect model based on the Cc in the model.
Changing functional forms of Effect models
- convertEmax() changes linear effect models to Emax models
- convertEmaxHill() changes linear effect models to Hill models
- convertQuad() changes linear effect models to quadratic models
- convertLogLin() changes linear effect models to log-linear models
Changing functional forms of Baselines in non-indirect response models
- addBaselineConst() changes the zero baseline to a estimated constant
- addBaselineLin() changes the zero baseline to a estimated constant and a linear constant with respect to time.
- addBaselineExp() changes the zero baseline to a exponential decay with respect to time
- addBaseline1exp() -- the baseline effect is changed from zero to to an exponential approaching to a constant (with respect to time).
Changing model properties (all use addCmtProp())
- addBioavailability() adds bioavailability property to a compartment
- addRate() adds a modeled rate to a compartment
- addDur() adds modeled duration to a compartment
- addIni() adds an initial value to a compartment
- addLag() adds a lag time to the a compartment
Add Carlsson Petri (2021) liraglutide PK model
Add Cirincione (2017) exenatide immediate-release PK model
Add a variety of indirect response models
Add a variety of tumor growth inhibition models and move all oncology models into a new model database directory
Add a variety of double-absorption PK models
cp and related cpddSd and cppropSd were renamed to Cc, CcAddSd and CcPropSd (fix #70).
Multiple-endpoint models will have the DV column in the modeldb separated by commas.

Version 0.2.0

Work with the new rxode2 version 2.0.12 model() and ini() assignment methods.
Therapeutic-area specific models have begun being added.
Models can now give the user some additional information load via the message meta-data.
Models can now be in different directories. The change is for ease of maintaining the library, it is not a change that affects users.
A regression where addEta() did not change the parameter, related to a change in rxode2, was fixed.
addEta() detects where to add etas more robustly when covariates are on the parameter.