theopp: Pharmacokinetics of theophylline

In npde: Normalised Prediction Distribution Errors for Nonlinear Mixed-Effect Models

Pharmacokinetics of theophylline

Description

The theopp data frame has 132 rows and 5 columns of data from an experiment on the pharmacokinetics of theophylline.

Usage

theopp

Format

This data frame contains the following columns:

ID

an ordered factor with levels 1, ..., 12 identifying the subject on whom the observation was made. The ordering is by Time at which the observation was made.

Dose

dose of theophylline administered orally to the subject (mg/kg).

Time

time since drug administration when the sample was drawn (hr).

Conc

theophylline concentration in the sample (mg/L).

Wt

weight of the subject (kg).

Details

Boeckmann, Sheiner and Beal (1994) report data from a study by Dr. Robert Upton of the kinetics of the anti-asthmatic drug theophylline. Twelve subjects were given oral doses of theophylline then serum concentrations were measured at 11 time points over the next 25 hours.

These data are analyzed in Davidian and Giltinan (1995) and Pinheiro and Bates (2000) using a two-compartment open pharmacokinetic model.

These data are also available in the library datasets under the name Theoph in a slightly modified format and including the data at time 0. Here, we use the file in the format provided in the NONMEM installation path (see the User Guide for that software for details).

Source

Boeckmann, A. J., Sheiner, L. B. and Beal, S. L. (1994), NONMEM Users Guide: Part V, NONMEM Project Group, University of California, San Francisco.

Davidian, M. and Giltinan, D. M. (1995) Nonlinear Models for Repeated Measurement Data, Chapman & Hall (section 5.5, p. 145 and section 6.6, p. 176)

Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer (Appendix A.29)

References

PDF documentation for npde 3.0: https://github.com/ecomets/npde30/blob/main/userguide_npde_3.0.pdf

Examples

data(theopp)

#Plotting the theophylline data
plot(Conc~Time,data=theopp,xlab="Time after dose (hr)",
ylab="Theophylline concentration (mg/L)")

npde documentation built on May 29, 2024, 9:59 a.m.