virload | R Documentation |

This is simulated data, based on real data obtained in a phase II clinical trial supported by the French Agency for AIDS Research, the COPHAR 3-ANRS 134 trial (Goujard et al., 2010). The original study included 35 patients, who received a once daily dose containing atazanavir (300 mg), ritonavir (100 mg), tenofovir disoproxil (245 mg) and emtricitabine (200 mg) during 24 weeks. Viral loads were measured 6 times over a treatment period of 24 weeks (day 0, 28, 56, 84, 112, 168).

```
virload
```

This data frame contains the following columns:

- ID
an ordered factor with levels

`1`

, ...,`50`

identifying the subject on whom the observation was made. The ordering is by Time at which the observation was made.- Time
time since the beginning of the study (days)

- Log_VL
logarithm (base 10) of the viral load (copies/L)

- cens
indicator variable (cens=1 for censored data, cens=0 for observed data)

- ipred
individual predictions

The datasets were generated in a simulation study designed to evaluate the new method proposed to handle BQL data (Nguyen et al., 2011). Data was simulated using a simple bi-exponential HIV dynamic model describing the two-phase decline of viral load during anti-retroviral treatment.

The `virload`

data frame has 300 rows and 4 columns of data. The dataset was then censored at two different LOQ levels (LOQ=20 or 50~copies/mL) to generate two datasets containing different proportions of BQL data, creating the data frames `virload20`

and`virload50`

respectively

The file simvirload contains 500 simulations under the same model. A full version of the simulated data with 1000 simulations can be downloaded from the github for npde3.0: https://github.com/ecomets/npde30/blob/main/keep/data/simvirload.tab

Goujard, C., Barrail-Train, A., Duval, X., Nembot, G., Panhard, X., Savic, R., Descamps, D., Vrijens, B., Taburet, A., Mentre, F., and the ANRS 134 study group (2010).
Virological response to atazanavir, ritonavir and tenofovir/emtricitabine: relation to individual pharmacokinetic parameters and adherence measured by medication events monitoring system (MEMS) in naive HIV-infected patients (ANRS134 trial).
*International AIDS Society 2010*, Abstr WEPE0094.

PDF documentation for npde 3.0: https://github.com/ecomets/npde30/blob/main/userguide_npde_3.0.pdf

```
data(virload)
str(virload)
data(virload50)
# Plotting the data
plot(Log_VL~Time,data=virload,xlab="Time (d)",ylab="Viral loads, base 10 log-scale (cp/mL)")
plot(Log_VL~Time,data=virload50,xlab="Time (d)",ylab="Viral loads, base 10 log-scale (cp/mL)")
```

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