pedigreeLoops: Pedigree loops

In paramlink: Parametric Linkage and Other Pedigree Analysis in R

Pedigree loops

Description

Functions for identifying, breaking and restoring loops in pedigrees.

Usage

pedigreeLoops(x)

breakLoops(x, loop_breakers = NULL, verbose = TRUE)

tieLoops(x)

findLoopBreakers(x)

findLoopBreakers2(x)

Arguments

x	a linkdat object.
loop_breakers	either NULL (resulting in automatic selection of loop breakers) or a numeric containing IDs of individuals to be used as loop breakers.
verbose	a logical: Verbose output or not?

Details

Most of paramlink's handling of pedigree loops is done under the hood - using the functions described here - without need for explicit action from end users. When a linkdat object x is created, an internal routine detects if the pedigree contains loops, in which case x$hasLoops is set to TRUE. In analyses of x where loops must be broken (e.g. lod score computation or marker simulation), this is done automatically by calling breakLoops.

In some cases with complex inbreeding, it can be instructive to plot the pedigree after breaking the loops. Duplicated individuals are plotted with appropriate labels (see examples).

The function findLoopBreakers identifies a set of individuals breaking all inbreeding loops, but not marriage loops. These require more machinery for efficient detection, and paramlink does this is a separate function, findLoopBreakers2, utilizing methods from the igraph package. Since this is rarely needed for most users, igraph is not imported when loading paramlink, only when findLoopBreakers2 is called.

In practice, breakLoops first calls findLoopBreakers and breaks at the returned individuals. If the resulting linkdat object still has loops, findLoopBreakers2 is called to break any marriage loops.

Value

For breakLoops, a linkdat object in which the indicated loop breakers are duplicated. The returned object will also have a non-null loop_breakers entry, namely a matrix with the IDs of the original loop breakers in the first column and the duplicates in the second.

For tieLoops, a linkdat object in which any duplicated individuals (as given in the x$loop_breakers entry) are merged. For any linkdat object x, the call tieLoops(breakLoops(x)) should return x.

For pedigreeLoops, a list containing all inbreeding loops (not marriage loops) found in the pedigree. Each loop is represented as a list with elements 'top', a 'bottom' individual, 'pathA' (individuals forming a path from top to bottom) and 'pathB' (creating a different path from top to bottom, with no individuals in common with pathA). Note that the number of loops reported here counts all closed paths in the pedigree and will in general be larger than the genus of the underlying graph.

For findLoopBreakers and findLoopBreakers2, a numeric vector of individual ID's.

Examples

x = cousinsPed(1, child=TRUE)

# Make the child affected, and homozygous for rare allele.
x = swapAff(x, 9)
x = setMarkers(x, marker(x, 9, c(2,2), alleles=1:2, afreq=c(0.99, 0.01)))

# Compute the LOD score under a recessive model. Loops are automatically broken in lod().
x = setModel(x, 2)
LOD1 = lod(x, theta=0.1)
stopifnot(round(LOD1, 2) == 0.88)

# Or we can break the loop manually before computing the LOD:
loopfree = breakLoops(x, loop_breaker=8)
plot(loopfree)
LOD2 = lod(loopfree, theta=0.1)
stopifnot(all.equal(x, tieLoops(loopfree)))
stopifnot(all.equal(LOD1, LOD2))

# Pedigree with marriage loop: Double first cousins
if(requireNamespace("igraph", quietly = TRUE)) {
    y = doubleCousins(1, 1, child=TRUE)
    findLoopBreakers(y) # --> 9
    findLoopBreakers2(y) # --> 9 and 4
    breakLoops(y) # uses both 9 and 4
}

paramlink documentation built on April 15, 2022, 9:06 a.m.