Tox2nTTP: Compute the nTTP score baed on the observed toxicity.

In phase1RMD: Repeated Measurement Design for Phase I Clinical Trial

Description

Tox2nTTP use the design parameters to compute the nTTP score baed on the observed toxicity.

Usage

Tox2nTTP(tox = c(1,2,0),
 wm = matrix(c(0, 0.5, 0.75, 1 , 1.5,
 0, 0.5, 0.75, 1 , 1.5,
 0, 0 , 0 , 0.5, 1 ),
 byrow = T, ncol = 5),
 toxmax = 2.5)

Arguments

tox	Toxicity grades for the toxicity types.
wm	Clinical weight matrix, where toxicity types define the rows while the toxicity grades define the columns. Usually solicited from physicians.
toxmax	The normalization constant used in computing nTTP score. For details, see Ezzalfani et al(2013).

Details

The Tox2nTTP function calculates the nTTP values based on the weight matrix.

Value

nTTP value.

Examples

#data(tox_matrix)

# Simulate the operating characteristics of clinical trials:
#Tox2nTTP(tox = c(1,2,0))
 

phase1RMD documentation built on March 13, 2020, 1:40 a.m.