Description Usage Arguments Details Value Author(s) References
Estimation of potency and confidence limits as described at
page 480 in Ph.Eur (but with the Sums Of Squares
computed by
lm).
If complete data analyses is performed, then the slope and contrasts of intercepts are returned form the lm-fit, and confidence intervals for potency computed by Fieller's theorem.
1 2 3 4 5 6 7 8 9 10 11 12 |
data |
data.frame with the columns |
lmInteraction |
Linear model for ANOVA table - with Sums of Squares. |
lmRestricted |
Linear model with estimates of regression parameters for complete analysis - when missing values are present. |
dr |
The dilution ratio of the equally spaced dilutions, see data2assayFrame. |
response |
A character string giving the name of the
|
sampleLabels |
A vector of character strings giving the labels of the |
indexOfReference |
Index of the reference among the samples
given by |
StdName |
A character string identifying the reference in the columns "Sample" of the input data. |
sampleStepName |
A character string giving the name of the
|
dfAdj |
The needed adjustment of the number of degrees of freedom, if e.g. data are corrected for blocks, rows or columns, or if values are imputed before applying the model of the completely randomized design on block designs. |
factor |
A numeric (vector) to multiply on the estimated potency. |
alpha |
A real number, preferable between 0 and 1 - for the confidence interval. |
See page 480 in Ph.Eur.
A list of lists with variables named as at page 480 in Ph.Eur.
Jens Henrik Badsberg
Chapter 5.3. Statistical analysis. In EUROPEAN PHARMACOPOEIA version 8.0, 2014; 607-635.
Fieller, E.C.: The biological standardization of insulin. Supplement to the Journal of the Royal Statistical Society. 1940; Vol. VII., No. 1.
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