Description Usage Details Source References Examples
5.1.2. THREE-DOSE LATIN SQUARE DESIGN
1 | data("AgarDiffusionAssay")
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From Ph.Eur.:
The standard has an assigned potency of 4855 IU/mg. The test preparation has an assumed potency of 5600 IU/mg. For the stock solutions 25.2 mg of the standard is dissolved in 24.5 ml of solvent and 21.4 mg of the test preparation is dissolved in 23.95 ml of solvent. The final solutions are prepared by first diluting both stock solutions to 1/20 and further using a dilution ratio of 1.5. A Latin square is generated with the method described in Section 8.6 (see Table 5.1.2.-I). The responses of this routine assay are shown in Table 5.1.2.-II (inhibition zones in mm x 10). The treatment mean values are shown in Table 5.1.2.-III. A graphical representation of the data (see Figure 5.1.2.-I) gives no rise to doubt the normality or homogeneity of variance of the data.
The example can also be found at CombiStats - EDQM, Council of Europe (http://combistats.edqm.eu): http://combistats.edqm.eu/content/view/187/199/
Chapter 5.3. Statistical analysis. In EUROPEAN PHARMACOPOEIA version 8.0, 2014; 607-635.
1 2 3 4 5 6 7 8 9 | data(AgarDiffusionAssay); Agar <- AgarDiffusionAssay
Agar <- read.table(paste(system.file(package = "pla"),
"vignettes/PhEur/data/AntibioticAgarDiffusionAssay.txt",
sep = "/"), header = TRUE)
select <- c("Row", "Column", "Sample", "Dilution", "Response")
PHframe <- data2assayFrame(Agar[, select])
plaModel <- pla(Agar, design = "lsd",
assayTitle = "PhEur: Antibiotic agar diffusion assay")
plots <- plot(plaModel, plots = "all", mfrow = c(3, 4))
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