Description Usage Details Source References Examples
5.1.4. FIVE-DOSE MULTIPLE ASSAYWITH COMPLETELY RANDOMIZED DESIGN
1 | data("HepatitisB")
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From Ph.Eur.:
3 independent two-fold dilution series of 5 dilutions were prepared from each of the vaccines. After some additional steps in the assay procedure, absorbance's were measured. They are shown in Table 5.1.4.-I. The logarithms of the optical densities are known to have a linear relationship with the logarithms of the doses. The mean responses of the ln-transformed optical densities are listed in Table 5.1.4.-II. No unusual features are discovered in a graphical presentation of the data.
The example can also be found at CombiStats - EDQM, Council of Europe (http://combistats.edqm.eu): http://combistats.edqm.eu/content/view/189/199/
Chapter 5.3. Statistical analysis. In EUROPEAN PHARMACOPOEIA version 8.0, 2014; 607-635.
1 2 3 4 5 6 7 8 9 10 11 12 13 | data(HepatitisB); Data <- HepatitisB
cbbPalette <- c("#000000", "#009E73", "#e79f00", "#9ad0f3",
"#0072B2", "#D55E00", "#CC79A7", "#F0E442")
Data <- readAssayTable(paste(system.file(package = "pla"),
"vignettes/PhEur/data/HepatitisB.txt",
sep = "/"), fun = log)
plaModel <- plaCRD(Data,
assayTitle =
"PhEur: HepatitisB; Three hepatitis B vaccines against a standard")
plaModel
plots <- plot(plaModel)
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