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pleioh2g: Estimation of Pleiotropic Heritability from Genome-Wide Association Studies (GWAS) Summary Statistics
Provides tools to compute unbiased pleiotropic heritability estimates of complex diseases from genome-wide association studies (GWAS) summary statistics. We estimate pleiotropic heritability from GWAS summary statistics by estimating the proportion of variance explained from an estimated genetic correlation matrix (Bulik-Sullivan et al. 2015 <doi:10.1038/ng.3406>) and employing a Monte-Carlo bias correction procedure to account for sampling noise in genetic correlation estimates.
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Package details |
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| Author | Yujie Zhao [aut, cre] |
| Maintainer | Yujie Zhao <yujiezhao@hsph.harvard.edu> |
| License | GPL-3 |
| Version | 0.1.2 |
| Package repository | View on CRAN |
| Installation |
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