Cal_cor_pleiotropic_h2_corrected_single: Compute single pleioh2g for target disease after correction...

In pleioh2g: Estimation of Pleiotropic Heritability from Genome-Wide Association Studies (GWAS) Summary Statistics

Compute single pleioh2g for target disease after correction with referred disease index in the rg matrix and corrected ratio

Description

This function computes pleioh2g for the target disease after correction.

Usage

Cal_cor_pleiotropic_h2_corrected_single(
  rg_mat,
  h2g_T_single,
  corrected_weight_updated,
  plei_h2_idx
)

Arguments

rg_mat	genetic correlation matrix.
h2g_T_single	heritability for target diseases.
corrected_weight_updated	the ratio for correction
plei_h2_idx	index of the target disease in the rg_mat.

Value

pleioh2g value for the target disease after correction

Examples

data(Results_full_rg)
data(h2_vector)
plei_h2_idx<-1
h2g_T_single <- h2_vector[plei_h2_idx]
corrected_weight_updated <- 0.78
Cal_cor_pleiotropic_h2_corrected_single(Results_full_rg,h2g_T_single,
corrected_weight_updated,plei_h2_idx)

pleioh2g documentation built on March 9, 2026, 5:07 p.m.