tests/testthat/test-parsing.R

In rxode2parse: Parsing and Code Generation Functions for 'rxode2'

badParse <- function(desc, code) {
  test_that(desc, {
    expect_error(suppressMessages(rxode2parse(code)))
  })
}

goodParse <- function(desc, code) {
  test_that(desc, {
    expect_s3_class(rxode2parse(code), "rxModelVars")
  })
}

badParse("incorrect d/dt operator", "d/dt(y = 1);")

## Statements don't require ; now.
goodParse(
  "comments must be outside statements #1",
  "d/dt(y) = 1   # bad comment;")

goodParse(
  'missing end of statement ";" dosen\'t cause errors',
  paste(
    sep = "\n",
    "d/dt(depot) = -ka * depot",
    "d/dt(centr) =  ka * depot - kout * centr;"))

badParse(
  "arithmetic syntax error",
  paste(
    sep = "\n",
    "# comment, just to show error in line 3",
    "d/dt(y) = -ka;",
    "C1 = /y;"
  )
)

## added ** operator
goodParse("existing operator **",
          code = paste(
            sep = "\n",
            "d/dt(y) = -ka;",
            "C1 = ka *  y**2;"))
badParse("unexistent operator %",
         code = paste(
           sep = "\n",
           "remainder = 4 % 3;",
           "d/dt(y) = -ka;",
           "C1 = ka * y;"))

badParse(
  desc = 'incorrect "if" statement',
  code = paste(
    sep = "\n",
    "if(comed==0){",
    "   F = 1.0;",
    "else {", # missing "}"'
    "   F = 0.75;",
    "};",
    "d/dt(y) = F * y;"))

badParse(
  desc = "illegal variable name (starting w. a digit)",
  code = paste(
    sep = "\n",
    "F = 0.75;",
    "12foo_bar = 1.0/2.0;",
    "d/dt(y) = F * y;"))

goodParse(
  desc = "dot in variable name (ini0)",
  code = paste(
    sep = "\n",
    "F = 0.75;",
    "foo.bar = 1.0/2.0;",
    "d/dt(y) = F * y;"
  )
)

goodParse(
  desc = "dot in variable name in d/dt()",
  code = paste(
    sep = "\n",
    "d/dt(y_1) = F * y;", # okay
    "d/dt(y.1) = F * y;"
  ) # not okay
)

goodParse(
  desc = "leading dot in variable name",
  code = paste(
    sep = "\n",
    "F = 0.75;",
    ".foo.bar = 0.5;",
    "d/dt(y) = F * y;"
  )
)

goodParse(
  desc = "leading dot in variable name (ini0)",
  code = paste(
    sep = "\n",
    "F = 0.75;",
    ".foo.bar = 1.0/2.0;",
    "d/dt(y) = F * y;"
  )
)

goodParse(
  desc = "leading dot in variable name in d/dt()",
  code = paste(
    sep = "\n",
    "d/dt(y_1) = F * y;", # okay
    "d/dt(.y.1) = F * y;"
  ) # not okay
)

goodParse(
  desc = "leading dot in variable name",
  code = paste(
    sep = "\n",
    "F = 0.75;",
    ".foo.bar = 0.5;",
    "d/dt(y) = F * y;"))

badParse(
  desc = "Assignment with <<- not supported",
  "d/dt(y_1) <<- F*y")

goodParse(
  desc = "Assignment with <- supported #1",
  "d/dt(y_1) <- F*y")

goodParse(
  desc = "Assignment with <- supported #2",
  "y_1(0) <- 1;d/dt(y_1) = F*y_1")

goodParse(
  desc = "Assignment with <- supported #3",
  "y_2 <- 1;d/dt(y_1) = F*y"
)

goodParse(
  desc = "Assignment with <- supported #4",
  "y_2 <- 1+7;d/dt(y_1) = F*y"
)

goodParse(
  desc = "Assignment with <- supported #7",
  "d/dt(y_1) = F*y; df(y_1)/dy(y_1) <- 0"
)

badParse(
  desc = "Defining df(var1)/dy(var2) where var1 is not a state variable.",
  "
d/dt(y)  = dy
d/dt(dy) = mu*(1-y^2)*dy - y
## Jacobian
df(y)/dy(dy)  = 1
df(dy)/dy(y)  = -2*dy*mu*y - 1
df(dy)/dy(dy) = mu*(1-y^2)
df(mu)/dy(y)=0;
## Initial conditions
y(0) = 2
dy(0) = 0
## mu
mu = 1 ## nonstiff; 10 moderately stiff; 1000 stiff
"
)

badParse(
  desc = "Defining df(var1)/dy(var2) where var1 is not a state variable.",
  "
d/dt(y)  = dy
d/dt(dy) = mu*(1-y^2)*dy - y
## Jacobian
df(y)/dy(dy)  = 1
df(dy)/dy(y)  = -2*dy*mu*y - 1
df(dy)/dy(dy) = mu*(1-y^2)
df(mu)/dy(y)=0;
## Initial conditions
y(0) = 2
dy(0) = 0
## mu
mu = 1 ## nonstiff; 10 moderately stiff; 1000 stiff
"
)

goodParse(
  desc = "Defining df(var1)/dy(var2) where var1 is a state variable.",
  "
d/dt(y)  = dy
d/dt(dy) = mu*(1-y^2)*dy - y
## Jacobian
df(y)/dy(dy)  = 1
df(dy)/dy(y)  = -2*dy*mu*y - 1
df(dy)/dy(dy) = mu*(1-y^2)
## Initial conditions
y(0) = 2
dy(0) = 0
## mu
mu = 1 ## nonstiff; 10 moderately stiff; 1000 stiff
"
)

goodParse(
  desc = "Defining df(var1)/dy(var2) where var2 is a variable.",
  "
d/dt(y)  = dy
d/dt(dy) = mu*(1-y^2)*dy - y
## Jacobian
df(y)/dy(dy)  = 1
df(dy)/dy(y)  = -2*dy*mu*y - 1
df(dy)/dy(dy) = mu*(1-y^2)
df(dy)/dy(mu) = (1-y^2)*dy
## Initial conditions
y(0) = 2
dy(0) = 0
## mu
mu = 1 ## nonstiff; 10 moderately stiff; 1000 stiff
"
)

badParse(
  desc = "Defining df(var1)/dy(var2) where var2 is a calculated value.",
  "
d/dt(y)  = dy
d/dt(dy) = mu*(1-y^2)*dy - y
## Jacobian
df(y)/dy(dy)  = 1
df(dy)/dy(y)  = -2*dy*mu*y - 1
df(dy)/dy(dy) = mu*(1-y^2)
df(dy)/dy(mu) = (1-y^2)*dy
## Initial conditions
y(0) = 2
dy(0) = 0
## mu
mu = 1+bad ## nonstiff; 10 moderately stiff; 1000 stiff
"
)

goodParse(
  desc = "a*b/c^2",
  "d/dt(x)=a*b/c^2*x"
)

goodParse(
  desc = "a*b/c^2/d",
  "d/dt(x)=a*b/c^2/d*x"
)

goodParse(
  desc = "Transit as a compartment",
  "d/dt(transit) = -(1/mtt) * transit
        d/dt(depot)   =  (1/mtt) * transit - ka * depot
        d/dt(center)  = ka * depot - (cl/v1) * center - (q/v1) * center + (q/v2) * periph
        d/dt(periph)  = (q / v1) * center - (q / v2) * periph
        cp = center / v1"
)

goodParse(
  desc = "=+ parsing",
  "C2 = +centr/V2;
              C3 = peri/V3;
              d/dt(depot) =-KA*depot;
              d/dt(centr) = +KA*depot - CL*C2 - Q*C2 + Q*C3;
              d/dt(peri)  =                    Q*C2 - Q*C3;
              d/dt(eff)  = Kin - Kout*(1-C2/(EC50+C2))*eff;"
)

for (v in c("ii", "evid")) {
  badParse(
    desc = sprintf("bad variables: %s", v),
    sprintf("var=%s", v)
  )
}
for (v in "tlast") {
  goodParse(
    desc = sprintf("good variables: %s", v),
    sprintf("var=%s", v)
  )
}
for (v in "abs") {
  goodParse(
    desc = sprintf("good functions: %s", v),
    sprintf("var=%s(x)", v)
  )
}

badParse(desc = "No duplicate dvid()", "a=b;dvid(1,2,3);dvid(3,4,5)")

badParse(desc = "Bad dvid(0)", "a=b;dvid(0);")
badParse(desc = "Bad dvid(0, 1)", "a=b;dvid(1,0);")

goodParse(desc = "THETA/ETA parsing", "a=THETA[1]+ETA[2];")

goodParse(desc = "Duplicate d/dt(x)", "d/dt(depot) = -depot*ka;\nd/dt(depot) = d/dt(depot)+0")

goodParse(desc = "Duplicate d/dt(x)", "d/dt(depot) ~ -depot*ka;\nd/dt(depot) = d/dt(depot)+0")
goodParse(desc = "Duplicate d/dt(x)", "d/dt(depot) = -depot*ka;\nd/dt(depot) ~ d/dt(depot)+0")

goodParse(desc = "pi Parse", "a = pi+e2")

for (v in c("f", "F", "alag", "lag", "rate", "dur")) {
  badParse(
    sprintf("%s cannot depend on d/dt(state)", v),
    sprintf("d/dt(depot)=-depot*ka;\nd/dt(central)=ka*depot-kel*central\n%s(depot)=d/dt(central)+3", v)
  )
}

badParse(desc = "Using d/dt(x) before defined", "y=d/dt(x)+3")

goodParse(
  desc = "Jacobain with theta and eta",
  "d/dt(x)=(THETA[1]+ETA[1])*x\ndf(x)/dy(THETA[1]) = 1\ndf(x)/dy(ETA[1]) = 1\n"
)


for (v in c("f", "F", "alag", "lag", "rate", "dur")) {
  badParse(
    sprintf("%s cannot depend on jacobain info", v),
    sprintf("d/dt(x)=(THETA[1]+ETA[1])*x\ndf(x)/dy(THETA[1]) = 1\ndf(x)/dy(ETA[1]) = 1\n%s(x)=df(x)/dt(ETA[1])+3", v)
  )
}

badParse(
  "mtime cannot depend on df(x)/dt(ETA[1])",
  "d/dt(x)=(THETA[1]+ETA[1])*x\ndf(x)/dy(THETA[1]) = 1\ndf(x)/dy(ETA[1]) = 1\nmtime(z)=df(x)/dt(ETA[1])+3"
)
badParse(
  "mtime cannot depend on d/dt(x)",
  "d/dt(x)=(THETA[1]+ETA[1])*x\ndf(x)/dy(THETA[1]) = 1\ndf(x)/dy(ETA[1]) = 1\nmtime(z)=d/dt(x)+3"
)

goodParse(
  "functional initialization ok",
  "x(0) = y + 3\nd/dt(x) =-3*z"
)

## 'rate' and 'dur' can be data items, so they cannot be variables
## in an rxode2 model
for (var in c("alag", "f", "F")) {
  goodParse(
    sprintf("Parsing of %s as a variable and function work.", var),
    sprintf("d/dt(x) = -k*x;%s(x) = %s;", var, var)
  )
}

goodParse("x=ifelse(!matt,0,1)", "x=ifelse(!matt,0,1)")
goodParse("x=ifelse(!(matt),0,1)", "x=ifelse(!(matt),0,1)")
goodParse("x=ifelse((!matt),0,1)", "x=ifelse((!matt),0,1)")

goodParse("mix lincmt with lags etc", "popCl <- 1
    popV <- 20
    popKa <- 1
    popVp <- 10
    popQ <- 2
    bsvCl <-0
    bsvV <- 0
    bsvKa <-0
    bsvVp <- 0
    bsvQ <-0
    popKeo <- 1.4
    bsvKeo <- 0
    popE0 <- 0
    popEmax <- 1
    popEC50 <- 5
    popGamma <- 1
    bsvE0 <- 0
    bsvEmax <- 0
    bsvEC50 <- 0
    ##
    cl ~ popCl * exp(bsvCl)
    v ~ popV * exp(bsvV)
    ka ~ popKa * exp(bsvKa)
    q ~ popQ * exp(bsvQ)
    vp ~ popVp * exp(bsvVp)
    keo ~ popKeo * exp(bsvKeo)
    popLagDepot <- 0
    popLagCentral <- 0
    popRateCentral <- 0
    popDurCentral <- 0
    bsvLagDepot <- 0
    bsvLagCentral <- 0
    bsvRateCentral <- 0
    bsvDurCentral <- 0
    alag(depot) <- popLagDepot * exp(bsvLagDepot)
    alag(central) <- popLagCentral * exp(bsvLagCentral)
    rate(central) <- popRateCentral * exp(bsvRateCentral)
    dur(central) <- popDurCentral * exp(bsvDurCentral)
    cp <- linCmt()
    d/dt(ce) = keo*(cp-ce)
    effect = E0 - Emax*(Ce^gamma)/((Ce^gamma)+(Ec50^gamma));")

badParse(
  "Still cannot take undefined compartments",
  "popCl <- 1
    popV <- 20
    popKa <- 1
    popVp <- 10
    popQ <- 2
    bsvCl <-0
    bsvV <- 0
    bsvKa <-0
    bsvVp <- 0
    bsvQ <-0
    popKeo <- 1.4
    bsvKeo <- 0
    popE0 <- 0
    popEmax <- 1
    popEC50 <- 5
    popGamma <- 1
    bsvE0 <- 0
    bsvEmax <- 0
    bsvEC50 <- 0
    ##
    cl ~ popCl * exp(bsvCl)
    v ~ popV * exp(bsvV)
    ka ~ popKa * exp(bsvKa)
    q ~ popQ * exp(bsvQ)
    vp ~ popVp * exp(bsvVp)
    keo ~ popKeo * exp(bsvKeo)
    popLagDepot <- 0
    popLagCentral <- 0
    popRateCentral <- 0
    popDurCentral <- 0
    bsvLagDepot <- 0
    bsvLagCentral <- 0
    bsvRateCentral <- 0
    bsvDurCentral <- 0
    alag(depot) <- popLagDepot * exp(bsvLagDepot)
    alag(central) <- popLagCentral * exp(bsvLagCentral)
    rate(central) <- popRateCentral * exp(bsvRateCentral)
    dur(central) <- popDurCentral * exp(bsvDurCentral)
    dur(matt) <- 3
    cp <- linCmt()
    d/dt(ce) = keo*(cp-ce)
    effect = E0 - Emax*(Ce^gamma)/((Ce^gamma)+(Ec50^gamma));"
)

badParse("cmt(depot) doesn't work with linCmt()", "popCl <- 1
    cmt(depot)
    popV <- 20
    popKa <- 1
    popVp <- 10
    popQ <- 2
    bsvCl <-0
    bsvV <- 0
    bsvKa <-0
    bsvVp <- 0
    bsvQ <-0
    popKeo <- 1.4
    bsvKeo <- 0
    popE0 <- 0
    popEmax <- 1
    popEC50 <- 5
    popGamma <- 1
    bsvE0 <- 0
    bsvEmax <- 0
    bsvEC50 <- 0
    ##
    cl ~ popCl * exp(bsvCl)
    v ~ popV * exp(bsvV)
    ka ~ popKa * exp(bsvKa)
    q ~ popQ * exp(bsvQ)
    vp ~ popVp * exp(bsvVp)
    keo ~ popKeo * exp(bsvKeo)
    popLagDepot <- 0
    popLagCentral <- 0
    popRateCentral <- 0
    popDurCentral <- 0
    bsvLagDepot <- 0
    bsvLagCentral <- 0
    bsvRateCentral <- 0
    bsvDurCentral <- 0
    alag(depot) <- popLagDepot * exp(bsvLagDepot)
    alag(central) <- popLagCentral * exp(bsvLagCentral)
    rate(central) <- popRateCentral * exp(bsvRateCentral)
    dur(central) <- popDurCentral * exp(bsvDurCentral)
    cp <- linCmt()
    d/dt(ce) = keo*(cp-ce)
    effect = E0 - Emax*(Ce^gamma)/((Ce^gamma)+(Ec50^gamma));")

badParse("cmt(central) doesn't work with linCmt()", "popCl <- 1
    cmt(central)
    popV <- 20
    popKa <- 1
    popVp <- 10
    popQ <- 2
    bsvCl <-0
    bsvV <- 0
    bsvKa <-0
    bsvVp <- 0
    bsvQ <-0
    popKeo <- 1.4
    bsvKeo <- 0
    popE0 <- 0
    popEmax <- 1
    popEC50 <- 5
    popGamma <- 1
    bsvE0 <- 0
    bsvEmax <- 0
    bsvEC50 <- 0
    ##
    cl ~ popCl * exp(bsvCl)
    v ~ popV * exp(bsvV)
    ka ~ popKa * exp(bsvKa)
    q ~ popQ * exp(bsvQ)
    vp ~ popVp * exp(bsvVp)
    keo ~ popKeo * exp(bsvKeo)
    popLagDepot <- 0
    popLagCentral <- 0
    popRateCentral <- 0
    popDurCentral <- 0
    bsvLagDepot <- 0
    bsvLagCentral <- 0
    bsvRateCentral <- 0
    bsvDurCentral <- 0
    alag(depot) <- popLagDepot * exp(bsvLagDepot)
    alag(central) <- popLagCentral * exp(bsvLagCentral)
    rate(central) <- popRateCentral * exp(bsvRateCentral)
    dur(central) <- popDurCentral * exp(bsvDurCentral)
    cp <- linCmt()
    d/dt(ce) = keo*(cp-ce)
    effect = E0 - Emax*(Ce^gamma)/((Ce^gamma)+(Ec50^gamma));")

badParse("theta0", "a = theta[0]")
badParse("eta0", "a = eta[0]")
goodParse("theta1", "a = theta[1]")
goodParse("eta1", "a = eta[1]")
badParse("matt1", "a = matt[1]")

badParse("ifelse1", "ifelse=3")
badParse("ifelse2", "a=ifelse+3")
badParse("ifelse3", "d/dt(ifelse)=matt")

badParse("if1", "if=3")
badParse("if2", "a=if+3")
badParse("if3", "d/dt(if)=matt")


badParse("cmt1", "cmt=3")
goodParse("cmt2", "a=cmt+3")
badParse("cmt3", "d/dt(cmt)=matt")

badParse("dvid1", "dvid=3")
goodParse("dvid2", "a=dvid+3")
badParse("dvid3", "d/dt(dvid)=matt")

badParse("addl1", "addl=3")
goodParse("addl2", "a=addl+3")
badParse("addl3", "d/dt(addl)=matt")

badParse("ss1", "ss=3")
goodParse("ss2", "a=ss+3")
badParse("ss3", "d/dt(ss)=matt")

badParse("amt1", "amt=3")
goodParse("amt2", "a=amt+3")
badParse("amt3", "d/dt(amt)=matt")

badParse("rate1", "rate=3")
goodParse("rate2", "a=rate+3")
badParse("rate3", "d/dt(rate)=matt")

badParse("printf1", "printf=3")
badParse("printf2", "a=printf+3")
badParse("printf3", "d/dt(printf)=matt")

badParse("Rprintf1", "Rprintf=3")
badParse("Rprintf2", "a=Rprintf+3")
badParse("Rprintf3", "d/dt(Rprintf)=matt")

badParse("print1", "print=3")
badParse("print2", "a=print+3")
badParse("print3", "d/dt(print)=matt")

goodParse("sum1", "a=sum(1,2,3,a,b,c)")
goodParse("sum2", "a=lag(b, 1)")

goodParse("transit1", "a=transit(n, mtt, bio)")
goodParse("transit2", "a=transit(n, mtt)")
badParse("transit3", "a=transit(n, mtt, bio,ack)")

goodParse("fun1", "a=is.nan(x)")
badParse("fun2", "a=is.nan(x,b)")
badParse("fun3", "a=is.nan()")

goodParse("fun4", "a=is.finite(x)")
badParse("fun5", "a=is.finite(x,a)")
badParse("fun6", "a=is.finite()")

goodParse("fun7", "a=is.infinite(x)")
badParse("fun8", "a=is.infinite(x,a)")
badParse("fun9", "a=is.infinite()")

badParse("fun10", "t=tinf")
badParse("fun11", "time=tinf")

badParse("while/else", "a=1;while(1){a=a+3} else { a=3}")

goodParse("while", "a=1;while(1){a=a+3}")

goodParse("while-break", "a=1;while(1){a=a+3; break;}")
badParse("while-break-bad", "a=1;while(1){a=a+3;}; break;")

goodParse("Dotted initial conditions",
          paste(c("d/dt(C.A) = - 1",
                  "C.A(0) = A"), collapse="\n"))

goodParse("Less than expression",
          "a <- 3 < -1")

badParse("Double assignment",
         "a <- 3 <- 1")

badParse("Double assignment#2",
          "a = 3 = 1")


test_that("after isn't shown or garbled", {
  t <-try(rxode2parse("a+b<-fun+fun  +  fun"))
  expect_true(inherits(t, "try-error"))
  print(attr(t,"condition")$message)
  expect_true(regexpr("after", attr(t,"condition")$message)==-1)
})

test_that("throws parsing error with wrong number of arguments", {
  .trans <- rxode2parseGetTranslation()
  expect_error(rxode2parse("a= llikNorm(a, b, c, d, f)"))

  .trans2 <- .trans
  .w <- which(.trans2$rxFun=="llikNorm")
  .trans2$argMax[.w] <- 4L
  rxode2parseAssignTranslation(.trans2)

  expect_error(rxode2parse("a= llikNorm(a, b, c, d, f)"))

  .trans2$argMax[.w] <- 2L
  rxode2parseAssignTranslation(.trans2)

  expect_error(rxode2parse("a= llikNorm(a, b, c, d, f)"))

  rxode2parseAssignTranslation(.trans)
  .trans2 <- .trans
  expect_true(rxode2parse("a=llikNorm(a, b, c)")$flags["thread"] == 1L)

  # pretend that llikNorm is not thread safe
  .trans2$threadSafe[.w] <- 0L
  rxode2parseAssignTranslation(.trans2)

  expect_true(rxode2parse("a=llikNorm(a, b, c)")$flags["thread"] == 0L)
  rxode2parseAssignTranslation(.trans)

  expect_error(rxode2parse("a=cos(b, c, d, e, f)"))
})


test_that("linear compartmental error", {
  expect_error(rxode2parse('f(central) <- 1 + f_study1 * (STUDYID == "Study 1")\nka <- exp(tka + eta.ka)\ncl <- exp(tcl + eta.cl)\nv <- exp(tv + eta.v)\ncp <- linCmt()', linear=TRUE), NA)
  expect_error(rxode2parse("params(THETA[1],THETA[2],THETA[3],THETA[4],THETA[5],THETA[6],ETA[1],ETA[2],ETA[3])\nrx_yj_~2\nrx_lambda_~1\nrx_hi_~1\nrx_low_~0\nrx_pred_=linCmtB(rx__PTR__, t, 0, 1, 1, 0, exp(ETA[2]+THETA[2]), exp(ETA[3]+THETA[3]), 0, 0, 0, 0, 0, 1, 0, 0, exp(ETA[1]+THETA[1]), 0, 1+(THETA[6]==1)*THETA[5], 0, 0)\nrx_r_=Rx_pow_di(THETA[4], 2)",
                           code="rxode2parse_test_code.c"), NA)
  expect_true(file.exists("rxode2parse_test_code.c"))
  if (file.exists("rxode2parse_test_code.c")) {
    lines <- readLines("rxode2parse_test_code.c")
    unlink("rxode2parse_test_code.c")
    expect_false(file.exists("rxode2parse_test_code.c"))
    expect_true(all(regexpr("THETA[6]", lines, fixed=TRUE) == -1))
  }

  mv <- rxode2parse("params(THETA[1],THETA[2],THETA[3],THETA[4],THETA[5],THETA[6],ETA[1],ETA[2],ETA[3])\nrx_yj_~2\nrx_lambda_~1\nrx_hi_~1\nrx_low_~0\nrx_pred_=linCmtB(rx__PTR__, t, 0, 1, 1, 0, exp(ETA[2]+THETA[2]), exp(ETA[3]+THETA[3]), 0, 0, 0, 0, 0, 1, 0, 0, exp(ETA[1]+THETA[1]), 0, 1+(THETA[6]==1)*THETA[5], 0, 0)\nrx_r_=Rx_pow_di(THETA[4], 2)")
  expect_false(any(mv$lhs == "rxlin___"))

  rxode2parse("ka <- 1\ncl <- 3.5\nvc <- 40\nConc <- linCmt()\nalag(depot) <- 1", linear=TRUE, code="rxode2parse_test_code.c")

  expect_true(file.exists("rxode2parse_test_code.c"))
  if (file.exists("rxode2parse_test_code.c")) {
    lines <- readLines("rxode2parse_test_code.c")
    unlink("rxode2parse_test_code.c")
    expect_false(file.exists("rxode2parse_test_code.c"))
    expect_true(any(regexpr("_alag[(&_solveData->subjects[_cSub])->linCmt]", lines, fixed=TRUE) != -1))
  }
  expect_error(rxode2parse("rx_yj_~2\nrx_lambda_~1\nrx_hi_~1\nrx_low_~0\nrx_pred_=1000*linCmtB(rx__PTR__,t,0,1,1,0,exp(ETA[1]+THETA[2]),exp(THETA[3]),0,0,0,0,0,1,0,0,exp(THETA[1]),exp(THETA[6]),1,0,0)\nrx__sens_rx_pred__BY_ETA_1___=1000*exp(ETA[1]+THETA[2])*linCmtB(rx__PTR__,t,0,1,1,1,exp(ETA[1]+THETA[2]),exp(THETA[3]),0,0,0,0,0,1,0,0,exp(THETA[1]),exp(THETA[6]),1,0,0)\nrx_r_=1e+06*Rx_pow_di(linCmtB(rx__PTR__,t,0,1,1,0,exp(ETA[1]+THETA[2]),exp(THETA[3]),0,0,0,0,0,1,0,0,exp(THETA[1]),exp(THETA[6]),1,0,0),2)*Rx_pow_di(THETA[5],2)+Rx_pow_di(THETA[4],2)\nrx__sens_rx_r__BY_ETA_1___=2e+06*exp(ETA[1]+THETA[2])*linCmtB(rx__PTR__,t,0,1,1,0,exp(ETA[1]+THETA[2]),exp(THETA[3]),0,0,0,0,0,1,0,0,exp(THETA[1]),exp(THETA[6]),1,0,0)*linCmtB(rx__PTR__,t,0,1,1,1,exp(ETA[1]+THETA[2]),exp(THETA[3]),0,0,0,0,0,1,0,0,exp(THETA[1]),exp(THETA[6]),1,0,0)*Rx_pow_di(THETA[5],2)\n"), NA)
})


test_that("TIME conundrums", {

  p <- rxode2parse("param(emax_fcfb,lec50,le0,let50_emax,propSd,etale0,TIME,PK);\ne0=exp(le0+etale0);\nemax=emax_fcfb;\nec50=exp(lec50);\net50_emax=exp(let50_emax);\nfoo=e0*(1+emax*(TIME/168)/(et50_emax+(TIME/168))*PK/(ec50+PK));\nrx_yj_~2;\nrx_lambda_~1;\nrx_low_~0;\nrx_hi_~1;\nrx_pred_f_~foo;\nrx_pred_~rx_pred_f_;\nrx_r_~(rx_pred_f_*propSd)^2;\nipredSim=rxTBSi(rx_pred_,rx_lambda_,rx_yj_,rx_low_,rx_hi_);\nsim=rxTBSi(rx_pred_+sqrt(rx_r_)*err.foo,rx_lambda_,rx_yj_,rx_low_,rx_hi_);\ncmt(foo);\ndvid(1);\n")

  expect_false(any(p$params == "TIME"))
  
})


test_that("pow problems", {
  expect_error(rxode2parse("pow=3+4"), NA)

  rxode2parse("pow=4\nif (CMT==5){pow = 3+1+pow(4, 3)}\npow2 = pow*2", code="rxode2parse_test_code.c")
  expect_true(file.exists("rxode2parse_test_code.c"))
  if (file.exists("rxode2parse_test_code.c")) {
    lines <- readLines("rxode2parse_test_code.c")
    unlink("rxode2parse_test_code.c")
    expect_false(file.exists("rxode2parse_test_code.c"))
    expect_true(any(regexpr("+pow(4,3)", lines, fixed=TRUE) != -1))
    expect_true(any(regexpr("_rxNotFun_pow=", lines, fixed=TRUE) != -1))
    expect_true(any(regexpr("=_rxNotFun_pow*2", lines, fixed=TRUE) != -1))
    expect_true(any(regexpr("(_CMT==5)", lines, fixed=TRUE)) != -1)
  }
})