sp23design: Design and Simulation of seamless Phase II-III Clinical Trials

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Provides methods for generating, exploring and executing seamless Phase II-III designs of Lai, Lavori and Shih using generalized likelihood ratio statistics. Includes pdf and source files that describe the entire R implementation with the relevant mathematical details.

Author
Balasubramanian Narasimhan [aut, cre], Mei-Chiung Shih [aut], Pei He [aut]
Date of publication
2014-06-26 00:13:09
Maintainer
Balasubramanian Narasimhan <naras@stat.stanford.edu>
License
LGPL-3
Version
0.9

View on CRAN

Man pages

analyzeSP23Design
Analyses the results of running a design. If a trial history,...
computeDGivenXi
Given the estimates of the pi and theta, compute d.
computeGammaSubT
Compute the estimate of the variance of the generalized...
computeResponseSummary
Given interim data, compute the response end-point summary
executeSP23Design
Given a design object, interim data and the current calendar...
exploreSP23Design
Explore a specified design by simulation
generateClinicalTrialData
A function to generate some clinical trial data according the...
generateInterimData
Generate interim data for a clinical trial from a data set.
generateSP23Design
Generate a seamless Phase II-III design object given some the...
hessian
A utility function to compute the hessian of the generalized...
loglik1
Compute the response log-likelihood
loglik1GivenDelta
Computes the constrained response log-likelihood (on the...
loglik2
Computes the survival log-likelihood
loglik2.repar0
Computes the constrained survival log-likelihood
mHP.b
Compute the modified Haybittle-Peto boundary
mHP.c
Compute the modified Haybittle-Peto boundary for the final...
performInterimLook
Perform an interim look in a seamless Phase II-III clinical...
resetSP23Design
Reset the design object so that counts and results are zeroed...
solveForCGivenABD
A convenience function to reduce dimension by solving for one...
sp23design-package
sp23design: A package for the design, exploration and...

Files in this package

sp23design
sp23design/inst
sp23design/inst/examples
sp23design/inst/examples/caseC.R
sp23design/inst/examples/run9.R
sp23design/inst/examples/run6.R
sp23design/inst/examples/caseG.R
sp23design/inst/examples/run4.R
sp23design/inst/examples/run2.R
sp23design/inst/examples/run1.R
sp23design/inst/examples/run5.R
sp23design/inst/examples/caseA.R
sp23design/inst/examples/run7.R
sp23design/inst/examples/caseE.R
sp23design/inst/examples/caseF.R
sp23design/inst/examples/run3.R
sp23design/inst/examples/caseD.R
sp23design/inst/examples/run8.R
sp23design/inst/examples/caseB.R
sp23design/inst/misc
sp23design/inst/misc/sp23design.Rnw
sp23design/inst/misc/makePDF.sh
sp23design/inst/misc/makePackage.sh
sp23design/inst/misc/README.txt
sp23design/inst/misc/Phase23.bib
sp23design/inst/doc
sp23design/inst/doc/sp23design.pdf
sp23design/inst/unitTests
sp23design/inst/unitTests/runitTests.R
sp23design/inst/unitTests/runTests.R
sp23design/NAMESPACE
sp23design/Changelog
sp23design/R
sp23design/R/sp23design.R
sp23design/MD5
sp23design/DESCRIPTION
sp23design/man
sp23design/man/mHP.c.Rd
sp23design/man/performInterimLook.Rd
sp23design/man/solveForCGivenABD.Rd
sp23design/man/generateInterimData.Rd
sp23design/man/sp23design-package.Rd
sp23design/man/mHP.b.Rd
sp23design/man/analyzeSP23Design.Rd
sp23design/man/executeSP23Design.Rd
sp23design/man/computeGammaSubT.Rd
sp23design/man/loglik2.Rd
sp23design/man/generateClinicalTrialData.Rd
sp23design/man/computeDGivenXi.Rd
sp23design/man/hessian.Rd
sp23design/man/loglik1GivenDelta.Rd
sp23design/man/loglik1.Rd
sp23design/man/computeResponseSummary.Rd
sp23design/man/resetSP23Design.Rd
sp23design/man/exploreSP23Design.Rd
sp23design/man/generateSP23Design.Rd
sp23design/man/loglik2.repar0.Rd