Provides methods for generating, exploring and executing seamless Phase II-III designs of Lai, Lavori and Shih using generalized likelihood ratio statistics. Includes pdf and source files that describe the entire R implementation with the relevant mathematical details.

Install the latest version of this package by entering the following in R:

`install.packages("sp23design")`

Author | Balasubramanian Narasimhan [aut, cre], Mei-Chiung Shih [aut], Pei He [aut] |

Date of publication | 2014-06-26 00:13:09 |

Maintainer | Balasubramanian Narasimhan <naras@stat.stanford.edu> |

License | LGPL-3 |

Version | 0.9 |

**analyzeSP23Design:** Analyses the results of running a design. If a trial history,...

**computeDGivenXi:** Given the estimates of the pi and theta, compute d.

**computeGammaSubT:** Compute the estimate of the variance of the generalized...

**computeResponseSummary:** Given interim data, compute the response end-point summary

**executeSP23Design:** Given a design object, interim data and the current calendar...

**exploreSP23Design:** Explore a specified design by simulation

**generateClinicalTrialData:** A function to generate some clinical trial data according the...

**generateInterimData:** Generate interim data for a clinical trial from a data set.

**generateSP23Design:** Generate a seamless Phase II-III design object given some the...

**hessian:** A utility function to compute the hessian of the generalized...

**loglik1:** Compute the response log-likelihood

**loglik1GivenDelta:** Computes the constrained response log-likelihood (on the...

**loglik2:** Computes the survival log-likelihood

**loglik2.repar0:** Computes the constrained survival log-likelihood

**mHP.b:** Compute the modified Haybittle-Peto boundary

**mHP.c:** Compute the modified Haybittle-Peto boundary for the final...

**performInterimLook:** Perform an interim look in a seamless Phase II-III clinical...

**resetSP23Design:** Reset the design object so that counts and results are zeroed...

**solveForCGivenABD:** A convenience function to reduce dimension by solving for one...

**sp23design-package:** sp23design: A package for the design, exploration and...

analyzeSP23Design | Man page |

computeDGivenXi | Man page |

computeGammaSubT | Man page |

computeResponseSummary | Man page |

executeSP23Design | Man page |

exploreSP23Design | Man page |

generateClinicalTrialData | Man page |

generateInterimData | Man page |

generateSP23Design | Man page |

hessian | Man page |

loglik1 | Man page |

loglik1GivenDelta | Man page |

loglik2 | Man page |

loglik2.repar0 | Man page |

mHP.b | Man page |

mHP.c | Man page |

performInterimLook | Man page |

resetSP23Design | Man page |

solveForCGivenABD | Man page |

sp23design | Man page |

sp23design-package | Man page |

inst

inst/examples

inst/examples/caseC.R
inst/examples/run9.R
inst/examples/run6.R
inst/examples/caseG.R
inst/examples/run4.R
inst/examples/run2.R
inst/examples/run1.R
inst/examples/run5.R
inst/examples/caseA.R
inst/examples/run7.R
inst/examples/caseE.R
inst/examples/caseF.R
inst/examples/run3.R
inst/examples/caseD.R
inst/examples/run8.R
inst/examples/caseB.R
inst/misc

inst/misc/sp23design.Rnw

inst/misc/makePDF.sh

inst/misc/makePackage.sh

inst/misc/README.txt

inst/misc/Phase23.bib

inst/doc

inst/doc/sp23design.pdf

inst/unitTests

inst/unitTests/runitTests.R
inst/unitTests/runTests.R
NAMESPACE

Changelog

R

R/sp23design.R
MD5

DESCRIPTION

man

man/mHP.c.Rd
man/performInterimLook.Rd
man/solveForCGivenABD.Rd
man/generateInterimData.Rd
man/sp23design-package.Rd
man/mHP.b.Rd
man/analyzeSP23Design.Rd
man/executeSP23Design.Rd
man/computeGammaSubT.Rd
man/loglik2.Rd
man/generateClinicalTrialData.Rd
man/computeDGivenXi.Rd
man/hessian.Rd
man/loglik1GivenDelta.Rd
man/loglik1.Rd
man/computeResponseSummary.Rd
man/resetSP23Design.Rd
man/exploreSP23Design.Rd
man/generateSP23Design.Rd
man/loglik2.repar0.Rd
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