computeGammaSubT: Compute the estimate of the variance of the generalized...
In sp23design: Design and Simulation of Seamless Phase II-III Clinical Trials
computeGammaSubT R Documentation
Compute the estimate of the variance of the generalized
likelihood ratio statistic at time t
Description
This function computes the variance of the generalized
likelihood ratio statistic at interim stopping times
Usage
computeGammaSubT(thetaHat, pi, interimData)
Arguments
thetaHat
The three-element vector of (α, β, γ)
pi
The two-element vector of (π_0, π_1)
interimData
The interim data at time t as a data frame
Details
The function builds a hessian matrix and uses a reparametrization to
compute Γ_t, the variance of the generalized likelihood
ration stochastic process at time
$t$.
Value
A scalar value of the variance Γ_t
Author(s)
Mei-Chiung Shih, Balasubramanian Narasimhan, Pei He
References
Lai, Tze Leung and Lavori, Philip W. and Shih, Mei-Chiung. Sequential
Design of Phase II-III Cancer Trials, Statistics in Medicine, Volume 31, issue 18, p.1944-1960, 2012.
sp23design documentation built on April 19, 2022, 5:08 p.m.
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| computeGammaSubT | R Documentation |
Compute the estimate of the variance of the generalized likelihood ratio statistic at time t
Description
This function computes the variance of the generalized likelihood ratio statistic at interim stopping times
Usage
computeGammaSubT(thetaHat, pi, interimData)
Arguments
thetaHat |
The three-element vector of (α, β, γ) |
pi |
The two-element vector of (π_0, π_1) |
interimData |
The interim data at time t as a data frame |
Details
The function builds a hessian matrix and uses a reparametrization to compute Γ_t, the variance of the generalized likelihood ration stochastic process at time $t$.
Value
A scalar value of the variance Γ_t
Author(s)
Mei-Chiung Shih, Balasubramanian Narasimhan, Pei He
References
Lai, Tze Leung and Lavori, Philip W. and Shih, Mei-Chiung. Sequential Design of Phase II-III Cancer Trials, Statistics in Medicine, Volume 31, issue 18, p.1944-1960, 2012.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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