Design and Simulation of seamless Phase II-III Clinical Trials

analyzeSP23Design | Analyses the results of running a design. If a trial history,... |

computeDGivenXi | Given the estimates of the pi and theta, compute d. |

computeGammaSubT | Compute the estimate of the variance of the generalized... |

computeResponseSummary | Given interim data, compute the response end-point summary |

executeSP23Design | Given a design object, interim data and the current calendar... |

exploreSP23Design | Explore a specified design by simulation |

generateClinicalTrialData | A function to generate some clinical trial data according the... |

generateInterimData | Generate interim data for a clinical trial from a data set. |

generateSP23Design | Generate a seamless Phase II-III design object given some the... |

hessian | A utility function to compute the hessian of the generalized... |

loglik1 | Compute the response log-likelihood |

loglik1GivenDelta | Computes the constrained response log-likelihood (on the... |

loglik2 | Computes the survival log-likelihood |

loglik2.repar0 | Computes the constrained survival log-likelihood |

mHP.b | Compute the modified Haybittle-Peto boundary |

mHP.c | Compute the modified Haybittle-Peto boundary for the final... |

performInterimLook | Perform an interim look in a seamless Phase II-III clinical... |

resetSP23Design | Reset the design object so that counts and results are zeroed... |

solveForCGivenABD | A convenience function to reduce dimension by solving for one... |

sp23design-package | sp23design: A package for the design, exploration and... |

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