mHP.c: Compute the modified Haybittle-Peto boundary for the final...
In sp23design: Design and Simulation of Seamless Phase II-III Clinical Trials

mHP.c

R Documentation

Compute the modified Haybittle-Peto boundary for the final look

Description

Compute the modified Haybittle-Peto boundary for the final look

Usage

mHP.c(mu = c(0, 0, 0), v = c(1, 2, 3), b = 3, alpha = 0.05,
      eps = 1/2, side = c("one", "two"))

Arguments

`mu`	the mean vector
`v`	The variance vector, usually proportional to information in calendar time
`b`	The (constant) modified Haybittle-Peto boundary, typically computed by `mHP.b`
`alpha`	The significance level desired
`eps`	The fraction of alpha to use
`side`	one-sided or two-sided (`one` or `two`)

Details

Compute the modified Haybittle-Peto boundary for the final look

Value

the modified Haybittle-Peto boundary for the final look

Author(s)

Mei-Chiung Shih, Balasubramanian Narasimhan, Pei He

References

Lai, Tze Leung and Lavori, Philip W. and Shih, Mei-Chiung. Sequential Design of Phase II-III Cancer Trials, Statistics in Medicine, Volume 31, issue 18, p.1944-1960, 2012.

sp23design documentation built on April 19, 2022, 5:08 p.m.