pk_iv_1cmt: Simulate PK data from a 1-compartment iv model

In vpc: Create Visual Predictive Checks

Description

Simulate PK data from a 1-compartment iv model

Usage

pk_iv_1cmt(
  t,
  t_inf = 1,
  tau = 24,
  dose = 120,
  CL = 0.345,
  Vc = 1.75,
  ruv = NULL
)

Arguments

t	Time after dose
t_inf	Infusion length
tau	Dosing interval
dose	Dose
CL	Clearance
Vc	Volume of distribution
ruv	Residual variability

Value

A vector of predicted values, with or without added residual variability

Examples

dat1 <- vpc:::pk_iv_1cmt(t = c(0:72), tau = 24, dose = 120, 
                   CL = 5, Vc = 50)
dat2 <- vpc:::pk_iv_1cmt(t = c(0:72), tau = 24, dose = 120, 
                   CL = 5, Vc = 50, 
                   ruv = list(proportional = 0.1, additive = 0.1))

vpc documentation built on Jan. 16, 2021, 5:44 p.m.