wnl: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis

This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.

Package details

AuthorKyun-Seop Bae [aut]
MaintainerKyun-Seop Bae <k@acr.kr>
URL https://cran.r-project.org/package=wnl
Package repositoryView on CRAN
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wnl documentation built on Sept. 6, 2021, 9:12 a.m.