This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis  Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turnover model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, invitro/invivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drugdrug interaction model, receptor occupancy model, and rebound phenomena model.
Package details 


Author  KyunSeop Bae [aut] 
Date of publication  20180614 11:42:54 UTC 
Maintainer  KyunSeop Bae <[email protected]r> 
License  GPL3 
Version  0.4.1 
URL  https://cran.rproject.org/package=wnl 
Package repository  View on CRAN 
Installation 
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