SolComp3: Get Lambdas and Coefficients of Three-compartment Model

In wnl: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis

Get Lambdas and Coefficients of Three-compartment Model

Description

It calculates lambdas and coefficients for three-compartment model from K10, K12, K21, K13, and K31.

Usage

SolComp3(K10, K12, K21, K13, K31)

Arguments

K10	Ke, Elimination rate constant from central compartment
K12	Rate constant from the central to the first peripheral compartment
K21	Rate constant from the first peripheral to the central compartment
K13	Rate constant from the central to the second peripheral compartment
K31	Rate constant from the second peripheral to the central compartment

Details

It calculates lambdas and coefficients of two-compartment model from K10, K12, and K21. Lambdas should have no identical values.

Value

This returns a list of lambdas and coefficients.

Author(s)

Kyun-Seop Bae <[e-mail]>

Examples

DAT
DAT2 = ExpandDH(DAT)
Sol = SolComp3(K10=0.1, K12=3, K21=1, K13=2, K31=0.5)
X3 = nComp(Sol, Ka=1, DAT2)
X3
matplot(DAT2[, "TIME"], X3, type="l")

wnl documentation built on April 25, 2023, 9:11 a.m.