wnl5: Old type WinNonlin - Least Square not MLE

In wnl: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis

Old type WinNonlin - Least Square not MLE

Description

It performs old type Winnonlin regression.

Usage

wnl5(Fx, Data, pNames, IE, LB, UB, Error="A", ObjFx=ObjLS)

Arguments

Fx	Function for structural model. It should return a vector of the same length to observations.
Data	Data table which will be used in Fx. Fx should access this with e$DATA.
pNames	Parameter names in the order of Fx arguments
IE	Initial estimates of parameters
LB	Lower bound for optim function. The default value is 0.
UB	Upper bound for optim function. The default value is 1e+06.
Error	Error model. One of "POIS" for Poisson error, "P" for proportional error, and others for additive error model.
ObjFx	Objective function to be minimized. The default is least square function.

Details

This uses scaled transformed parameters and environment e internally. Here we do not provide standard error. If you want standard error, use nlr.

Value

PE	Point estimates
WRSS	Weighted Residual Sum of Square
run$m	Count of positive residuals
run$n	Count of negative residuals
run$run	Count of runs of residuals
run$p.value	P value of run test with excluding zero points
Objective Function Value	Minimum value of the objective function
AIC	Akaike Information Criterion
SBC	Schwarz Bayesian Information Criterion
Condition Number	Condition number
Message	Message from optim.
Prediction	Fitted(predicted) values
Residuals	Residuals
Elapsed Time	Consumed time by minimization

Author(s)

Kyun-Seop Bae <[e-mail]>

Examples

tData = Theoph
colnames(tData) = c("ID", "BWT", "DOSE", "TIME", "DV")

fPK = function(THETA) # Prediction function
{
  DOSE = 320000 # in microgram
  TIME = e$DATA[,"TIME"] # use data in e$DATA

  K  = THETA[1]
  Ka = THETA[2]
  V  = THETA[3]
  Cp  = DOSE/V*Ka/(Ka - K)*(exp(-K*TIME) - exp(-Ka*TIME))
  return(Cp)
}

IDs = unique(tData[,"ID"])
nID = length(IDs)
for (i in 1:nID) {
  Data = tData[tData$ID == IDs[i],]
  Res = wnl5(fPK, Data, pNames=c("k", "ka", "V"), IE=c(0.1, 3, 500))
  print(paste("## ID =", i, "##"))
  print(Res)
}

wnl documentation built on Sept. 9, 2025, 5:45 p.m.