Secondary: Get Secondary Parameter Estimates

In wnl: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis

Get Secondary Parameter Estimates

Description

Get standard error and relative standard error (cv) of the secondary parameter estimate

Usage

Secondary(Formula, PE, COV)

Arguments

Formula	Formula to calculate the secondary parameter estimate
PE	Point estimates of primary parameters with names
COV	Variance-covariance matrix of primary estimates

Details

Variables within Formula should exist in the names of PE vector.

Value

This returns point estimate, standard error, relative standard error of the secondary parameter estimate.

Author(s)

Kyun-Seop Bae <[e-mail]>

Examples

tData = Theoph
colnames(tData) = c("ID", "BWT", "DOSE", "TIME", "DV") # Table requires DV column

fPK = function(THETA) # Prediction function
{
  AMT  = 320000 # in microgram
  TIME = e$DATA[,"TIME"]
  V  = THETA[1]
  K  = THETA[2]
  Ka = THETA[3]
  Cp = AMT/V*Ka/(Ka - K)*(exp(-K*TIME) - exp(-Ka*TIME))
  return(Cp)
}
Data = tData[tData$ID == 1,]
Res = nlr(fPK, Data, pNames=c("V", "K", "Ka"), IE=c(30000, 0.1, 2))
Secondary(~V*K, Res$Est["PE",1:e$nPara], Res$Cov)

wnl documentation built on April 25, 2023, 9:11 a.m.