examples/Simulations-method-plotSIMDualFlexi.R

In 0liver0815/onc-crmpack-test: Object-Oriented Implementation of CRM Designs

# nolint start

##obtain the plot for the simulation results
##If DLE and efficacy responses are considered in the simulations
data <- DataDual(doseGrid=seq(25,300,25))
##First for the DLE model
##The DLE model must be of 'ModelTox' (e.g 'LogisticIndepBeta') class
DLEmodel <- LogisticIndepBeta(binDLE=c(1.05,1.8),
                              DLEweights=c(3,3),
                              DLEdose=c(25,300),
                              data=data)

##The efficacy model must be of 'EffFlexi' class

Effmodel<- EffFlexi(Eff=c(1.223, 2.513),Effdose=c(25,300),
                    sigma2=c(a=0.1,b=0.1),sigma2betaW=c(a=20,b=50),smooth="RW2",data=data)

##The escalation rule using the 'NextBestMaxGainSamples' class
mynextbest<-NextBestMaxGainSamples(DLEDuringTrialtarget=0.35,
                                   DLEEndOfTrialtarget=0.3,
                                   TDderive=function(TDsamples){
                                     quantile(TDsamples,prob=0.3)},
                                   Gstarderive=function(Gstarsamples){
                                     quantile(Gstarsamples,prob=0.5)})

## The cohort size, size of 3 subjects
mySize <-CohortSizeConst(size=3)
##Deifne the increments for the dose-escalation process
##The maximum increase of 200% for doses up to the maximum of the dose specified in the doseGrid
##The maximum increase of 200% for dose above the maximum of the dose specified in the doseGrid
##This is to specified a maximum of 3-fold restriction in dose-esclation
myIncrements<-IncrementsRelative(intervals=c(min(data@doseGrid),max(data@doseGrid)),
                                 increments=c(2,2))
##Specified the stopping rule e.g stop when the maximum sample size of 36 patients has been reached
myStopping <- StoppingMinPatients(nPatients=36)


##Specified the design
design <- DualResponsesSamplesDesign(nextBest=mynextbest,
                                     cohortSize=mySize,
                                     startingDose=25,
                                     model=DLEmodel,
                                     Effmodel=Effmodel,
                                     data=data,
                                     stopping=myStopping,
                                     increments=myIncrements)
##specified the true DLE curve and the true expected efficacy values at all dose levels
myTruthDLE <- probFunction(DLEmodel, phi1 = -53.66584, phi2 = 10.50499)

myTruthEff<- c(-0.5478867, 0.1645417,  0.5248031,  0.7604467,
               0.9333009  ,1.0687031,  1.1793942 , 1.2726408 ,
               1.3529598 , 1.4233411 , 1.4858613 , 1.5420182)
##The true gain curve can also be seen
myTruthGain <- function(dose)
{return((myTruthEff(dose))/(1+(myTruthDLE(dose)/(1-myTruthDLE(dose)))))}


##options for MCMC
options<-McmcOptions(burnin=10,step=1,samples=20)
##The simulations
##For illustration purpose only 1 simulation is produced (nsim=1).
mySim<-simulate(object=design,
                args=NULL,
                trueDLE=myTruthDLE,
                trueEff=myTruthEff,
                trueSigma2=0.025,
                trueSigma2betaW=1,
                mcmcOptions=options,
                nsim=1,
                seed=819,
                parallel=FALSE)
##plot this simulated results
print(plot(mySim))

# nolint end