README.md

In ConesaLab/MORE: Multi-Omics REgulation (MORE)

This repository has been migrated to BiostatOmics. Please redirect to the new repository for the latest updates and contributions.

MORE

MORE (Multi-Omics REgulation) is an R package for the application of Generalized Linear Models (GLM) with Elastic Net regularization or Partial Least Squares (PLS) to multi-omics data. The MORE method applies GLMs or PLS to model gene expression as a function of experimental variables, such as diseases or treatments, and the potential regulators of a given gene. The aim is to obtain specific candidate regulators for the biological system under study.

Installing

Currently, the package can be installed directly from GitHub using the devtools R package:

install.packages("devtools")
devtools::install_github("ConesaLab/MORE")

Before installation, it might be necessary to install the required dependencies:

• glmnet
• igraph
• MASS
• psych
• car
• ltm
• ropls
• stringr

Usage

You can find the User Guide for the package in the vignettes folder or access it directly here.

MORE can also be run as a Shiny application. In this directory you will find .zip file containing all the required inputs to run it.

You can find more information on how to run MORE as a Shiny app in the User Guide, and also in the following video.

ConesaLab/MORE documentation built on March 7, 2024, 6:44 p.m.