The three most important arguments
1 2 3 4 5 6 7 8 9 10 | RSSp_estimate(
quh,
D,
sample_size = NULL,
trait_id = gen_trait_uuid(),
pve_bounds = c(.Machine$double.eps, 1 - .Machine$double.eps),
nterms = 1,
p = sum(D),
useGradient = T
)
|
quh |
transformed summary statistics |
D |
vector of eigenvalues of the reference LD matrix |
sample_size |
sample size of GWAS |
trait_id |
identifier for the trait |
pve_bounds |
boundaries for pve estimation |
nterms |
number of terms in the model, by default there is one term that corresponds to heritability |
p |
number of variants in the dataset. By default (and in almost all scenarios) this is the sum of the eigenvalues. |
useGradient |
a boolean indicating whether or not to optimize using an analytic form for the gradient. |
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