generate_mutation: Generate CRISPR induced mutations

In Galaxeee/TedSim: Temporal Dynamics Simulation of scRNA-seq and CRISR/Cas9 lineage barcodes

Generate CRISPR induced mutations

Description

Generate CRISPR induced mutations

Usage

generate_mutation(
  barcode,
  mu = 0.1,
  N_ms = 100,
  mutation_dist = NULL,
  p_d = 0,
  unif_on = FALSE
)

Arguments

barcode	input barcode (from the parent cell)
mu	mutation rate per target, default is 1
N_ms	the number of mutated states required
mutation_dist	input distribution for the mutated states
p_d	whether or not to simulate dropout effects, 0 or 1
unif_on	distribution mode of mutated states. TRUE: uniform distribution; FALSE: real fitted distribution

Galaxeee/TedSim documentation built on Oct. 2, 2022, 1:25 a.m.