inst/testScripts/system/chipTypes/GenomeWideSNP_5/21.doASCRMAv2.R

In HenrikBengtsson/aroma.affymetrix: Analysis of Large Affymetrix Microarray Data Sets

library("aroma.affymetrix")
verbose <- Verbose(threshold=-8, timestamp=TRUE)

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# Setup
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dataSet <- "Affymetrix-HapMap,CEU,set1"
chipType <- "GenomeWideSNP_5"

cdf <- AffymetrixCdfFile$byChipType(chipType, tags="Full,r2")
print(cdf)

csR <- AffymetrixCelSet$byName(dataSet, cdf=cdf)

# Split up into names and tags
setFullNamesTranslator(csR, function(names, ...) {
  gsub("^(NA[0-9]+)_(.*)", "\\1,\\2", names)
})

# Drop duplicates
keep <- !duplicated(getNames(csR))
csR <- csR[keep]

# Keep only certain samples
sampleNames <- c("NA06985", "NA06991", "NA06993",
                 "NA07019", "NA07022", "NA07056")
csR <- csR[sampleNames]

print(csR)


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# AS-CRMAv2
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res <- doASCRMAv2(csR, drop=FALSE, verbose=verbose)
print(res)


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# Segmentation
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dsNList <- res$dsNList

seg <- CbsModel(dsNList$total)
print(seg)

ce <- ChromosomeExplorer(seg)
print(ce)
process(ce, arrays=1, chromosomes=c(19,23), verbose=verbose)