getUS_regulators: Get upstream regulators of identified transcription factors.

In MarenS2/pwOmics: Pathway-based data integration of omics data

Description

Get upstream regulators of identified transcription factors.

Usage

getUS_regulators(data_omics)

Arguments

data_omics

OmicsData object.

Value

list of length = number of gene/transcript time points, each element containing a vector of protein regulator IDs.

Examples

## Not run: 
data(OmicsExampleData)
data_omics = readOmics(tp_prots = c(0.25, 1, 4, 8, 13, 18, 24), 
tp_genes = c(1, 4, 8, 13, 18, 24), OmicsExampleData,
PWdatabase = c("biocarta", "kegg", "nci", "reactome"), 
TFtargetdatabase = c("userspec"))
data_omics = readPhosphodata(data_omics, 
phosphoreg = system.file("extdata", "phospho_reg_table.txt", 
package = "pwOmics.newupdown")) 
data_omics = readTFdata(data_omics, 
TF_target_path = system.file("extdata", "TF_targets.txt", 
package = "pwOmics.newupdown"))
data_omics_plus = readPWdata(data_omics,  
loadgenelists = system.file("extdata/Genelists", package = "pwOmics.newupdown"))
data_omics_plus = identifyPR(data_omics_plus)

## End(Not run)
## Not run: 
setwd(system.file("extdata/Genelists", package = "pwOmics.newupdown"))
data_omics = identifyPWs(data_omics_plus)
data_omics = identifyTFs(data_omics)
data_omics = identifyRsofTFs(data_omics, 
noTFs_inPW = 1, order_neighbors = 10)
getUS_regulators(data_omics)

## End(Not run)

MarenS2/pwOmics documentation built on May 17, 2019, 9:10 a.m.