Description Usage Arguments Value Author(s) References See Also Examples
given two vectors of diseases, a list of disease-gene associations , and a list of gene-gene log-likelihood score from HumanNet, this function will calculate disease similarity by method FunSim
1 | FunSim(D1, D2, d2g, LLSnList)
|
D1 |
a vector consists disease ids |
D2 |
another vector consists disease ids |
d2g |
a list of disease-gene associations, while gene ids should be entrez id. |
LLSnList |
a list of gene-gene log-likelihood score from HumanNet |
a matrix of disease disease simialrity which rownames is D1 and colnames is D2
Peng Ni, Min Li
Cheng L, Li J, Ju P, et al. SemFunSim: a new method for measuring disease similarity by integrating semantic and gene functional association[J]. PloS one, 2014, 9(6): e99415.
1 2 3 4 5 6 7 8 9 | ## in this method, we must use disease-gene associations
## which genes are represented by entrez ids because of
## HumanNet
data(d2g_fundo_entrezid)
data(HumanNet_sample)
## we specified 5 DOIDs to match Human_sample
ds<-c("DOID:8176","DOID:2394","DOID:3744","DOID:8466","DOID:5679")
llsnlist<-LLSn2List(HumanNet_sample)
FunSim(ds,ds,d2g_fundo_entrezid,llsnlist)
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