examples/Rules-method-size-CohortSizeMax.R

In Roche/crmPack: Object-Oriented Implementation of CRM Designs

# nolint start

# Create the data
data <- Data(
  x = c(0.1, 0.5, 1.5, 3, 6, 10, 10, 10),
  y = c(0, 0, 0, 0, 0, 0, 1, 0),
  cohort = c(0, 1, 2, 3, 4, 5, 5, 5),
  doseGrid =
    c(
      0.1, 0.5, 1.5, 3, 6,
      seq(from = 10, to = 80, by = 2)
    )
)

# Initialize the CRM model used to model the data
model <- LogisticLogNormal(
  mean = c(-0.85, 1),
  cov =
    matrix(c(1, -0.5, -0.5, 1),
      nrow = 2
    ),
  ref_dose = 56
)

# Set-up some MCMC parameters and generate samples from the posterior
options <- McmcOptions(
  burnin = 100,
  step = 2,
  samples = 2000
)
set.seed(94)
samples <- mcmc(data, model, options)

# Define the rule for dose increments and calculate the maximum dose allowed
myIncrements <- IncrementsRelative(
  intervals = c(0, 20),
  increments = c(1, 0.33)
)
nextMaxDose <- maxDose(myIncrements,
  data = data
)

# Define the rule which will be used to select the next best dose
# based on the class 'NextBestNCRM'
myNextBest <- NextBestNCRM(
  target = c(0.2, 0.35),
  overdose = c(0.35, 1),
  max_overdose_prob = 0.25
)

# Calculate the next best dose
doseRecommendation <- nextBest(myNextBest,
  doselimit = nextMaxDose,
  samples = samples, model = model, data = data
)

# Rule for having cohort of size 1 for doses <30
#      and having cohort of size 3 for doses >=30
mySize1 <- CohortSizeRange(
  intervals = c(0, 10),
  cohort_size = c(1, 3)
)

# Rule for having cohort of size 1 until no DLT were observed
#      and having cohort of size 3 as soon as 1 DLT is observed
mySize2 <- CohortSizeDLT(
  intervals = c(0, 1),
  cohort_size = c(1, 3)
)

# Combining the two rules for cohort size by taking the maximum of the sample sizes
# of the single rules
mySize <- maxSize(mySize1, mySize2)

# Determine the cohort size for the next cohort
size(mySize, dose = doseRecommendation$value, data = data)

# nolint end