R/calcSQ.R

In UW-GAC/GENESIS: GENetic EStimation and Inference in Structured samples (GENESIS): Statistical methods for analyzing genetic data from samples with population structure and/or relatedness

.computeSigmaQuantities <- function(varComp, covMatList, group.idx = NULL, vmu = NULL, gmuinv = NULL){
    m <- length(covMatList)
    n <- nrow(covMatList[[1]])

    # contribution to Sigma from random effects
    Vre <- Reduce("+", mapply("*", covMatList, varComp[1:m], SIMPLIFY=FALSE))

    if (is.null(vmu)){
        # gaussian family
        # contribution to Sigma from residual variance
        if (is.null(group.idx)){
            diagV <- rep(varComp[m+1],n)
        } else{
            g <- length(group.idx)
            diagV <- rep(NA, n)
            for(i in 1:g){
                diagV[group.idx[[i]]] <- varComp[m+i]
            }
        }

    } else {
        # non-gaussian family
        diagV <- as.vector(vmu)/as.vector(gmuinv)^2
    }

    # construct Sigma
    Sigma <- Vre
    diag(Sigma) <- diag(Sigma) + diagV   
    # cholesky decomposition
    cholSigma <- chol(Sigma)
    # inverse
    Sigma.inv <- chol2inv(cholSigma)

    return(list(Sigma.inv = Sigma.inv, Vre = Vre, W = 1/diagV, cholSigma.diag = diag(cholSigma)))
    # W is the diagonal matrix needed for fast.score.SE
}