README.md
In aiminy/ModifiedDOSE: Disease Ontology Semantic and Enrichment analysis

DOSE: Disease Ontology Semantic and Enrichment analysis

This package implements five methods proposed by Resnik, Schlicker, Jiang, Lin and Wang respectively for measuring semantic similarities among DO terms and gene products. Enrichment analyses including hypergeometric model and gene set enrichment analysis are also implemented for discovering disease associations of high-throughput biological data.

Please cite the following article when using DOSE:

G Yu, LG Wang, GR Yan, QY He. DOSE: an R/Bioconductor package for Disease Ontology Semantic and Enrichment analysis. Bioinformatics 2015, 31(4):608-609.

For details, please visit our project website, https://guangchuangyu.github.io/DOSE.

    +-+---------+---------+---------+---------+--------+---+
 10 +                                                  *   +
    |                                                      |
9.8 +                                                      +
    |                                                      |
9.6 +                                                      +
    |                                                      |
    |                                                      |
9.4 +                                                      +
    |                                                      |
9.2 +                                                      +
    |                                                      |
  9 + *                                                    +
    +-+---------+---------+---------+---------+--------+---+
    2015     2015.2    2015.4    2015.6    2015.8    2016

     +-----------+---------------+---------------+----------------+---------------+---------------++
     |                                                                                  *  *       |
     |                                                                                      *      |
     |                                                                                    *        |
2000 +                                                                                 *      *    +
     |                                                                                             |
     |                                                                                             |
     |                                                                                             |
     |                                                                                             |
1500 +                                                                                *            +
     |                                                                             *               |
     |                                                                     * * ** *                |
     |                                                                      *       *              |
1000 +                                                                 * *                         +
     |                                                               *  *                          |
     |                                                      ** **  **                              |
     |                                                 *** *                                       |
     |                                  **     ***   *           *                                 |
 500 +                 *             * *    **     *                                               +
     |               *  *      **   *      *        *                                              |
     |              *    * ***   * *                                                               |
     |          ** *                                                                               |
   0 +   * *** *                                                                                   +
     +-----------+---------------+---------------+----------------+---------------+---------------++
               2012            2013            2014             2015            2016            2017