highedges: calculating edge scores, determining the change-point and...

highedgesR Documentation

calculating edge scores, determining the change-point and generating the KO-gene associated sub-graph

Description

It is not executed itself, instead, it is invoked by pathwayko.

Usage

highedges(
  KEGGgraph = NULL,
  DataObject = NULL,
  condition_FC = NULL,
  condition_pVal = NULL,
  mc.cores = 1
)

Arguments

KEGGgraph

graphical representation of pathways in KEGG

DataObject

Object generated by calling preprocess.R

condition_FC

named list of logFC of all genes in DataObject

condition_pVal

named list of adjusted pval of all genes in DataObject

mc.cores

number of cores to be used in parallel lapply

Details

Reference: Hanoudi S., et al. (2017) Identifying biologically relevant putative mechanisms in a given phenotype comparison. PLoS ONE 12, e0176950.

Value

various information grouped together as a list

Author(s)

Original implementation by Samer Hanoudi and Sorin Draghici, modification by Hannan Ai


allenaigit/pathwayko documentation built on Nov. 23, 2022, 5:43 p.m.