Description Usage Arguments Value References Examples

Conduct meta-analysis of variant-set association test of m variants assuming similar effects across variants.
RHE BT: *∑_k(η_k^TU_k)^2*; FE BT: *(∑_kη_k^TU_k)^2*; BAT: adaptively combine RHE BT and FE BT.

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`Us` |
matrix of variant test statistics (m by K) |

`Vs` |
array of covariance matrix for test statistics (m,m by K) |

`eta` |
coefficient matrix for variants (m by K). Default to equal weights. |

`rho` |
weights assigned to the FE BT |

- p.value
p-values for BAT, RHE BT, FE BT

- pval
vector of p-values for each rho

- rho.est
optimal rho value leading to the minimum p-value

Wu,B. and Zhao,H. (2018) Efficient and powerful meta-analysis of variant-set association tests using MetaSAT.

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baolinwu/MetaSAT documentation built on Nov. 4, 2018, 12:32 a.m.

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