Description Usage Arguments Value References Examples
Conduct meta-analysis of variant-set association test of m variants assuming heterogeous effects across K studies. HE VT: ∑_k U_k^TU_k; RHE BT: ∑_k(η_k^TU_k)^2; RAT: adaptively combine HE VT and RHE BT.
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Us |
matrix of variant test statistics (m by K) |
Vs |
array of covariance matrix for test statistics (m,m by K) |
eta |
coefficient matrix for variants (m by K). Default to equal weights. |
rho |
weights assigned to the RHE BT |
p-values for RAT, HE VT, RHE BT
vector of p-values for each rho
optimal rho value leading to the minimum p-value
Wu,B. and Zhao,H. (2018) Efficient and powerful meta-analysis of variant-set association tests using MetaSAT.
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