computeAmax: Fits dose-response curves to data given by the user and...

In bhklab/PharmacoGx: Analysis of Large-Scale Pharmacogenomic Data

Fits dose-response curves to data given by the user and returns the Amax of the fitted curve. Amax: 100 - viability at maximum concentarion (in fitted curve)

Description

Fits dose-response curves to data given by the user and returns the Amax of the fitted curve. Amax: 100 - viability at maximum concentarion (in fitted curve)

Usage

computeAmax(concentration, viability, trunc = TRUE, verbose = FALSE)

Arguments

concentration	numeric is a vector of drug concentrations.
viability	numeric is a vector whose entries are the viability values observed in the presence of the drug concentrations whose logarithms are in the corresponding entries of the log_conc, expressed as percentages of viability in the absence of any drug.
trunc	logical, if true, causes viability data to be truncated to lie between 0 and 1 before curve-fitting is performed.
verbose	logical should warnings be printed

Value

The numerical Amax

Examples

dose <- c(0.0025,0.008,0.025,0.08,0.25,0.8,2.53,8)
viability <- c(108.67,111,102.16,100.27,90,87,74,57)
computeAmax(dose, viability)

bhklab/PharmacoGx documentation built on April 18, 2024, 3:13 a.m.