computeSlope: Return Slope (normalized slope of the drug response curve)...

In bhklab/PharmacoGx: Analysis of Large-Scale Pharmacogenomic Data

Return Slope (normalized slope of the drug response curve) for an experiment of a pSet by taking its concentration and viability as input.

Description

Return Slope (normalized slope of the drug response curve) for an experiment of a pSet by taking its concentration and viability as input.

Usage

computeSlope(concentration, viability, trunc = TRUE, verbose = TRUE)

Arguments

concentration	numeric A concentration range that the AUC should be computed for that range. Concentration range by default considered as not logarithmic scaled. Converted to numeric by function if necessary.
viability	numeric Viablities corresponding to the concentration range passed as first parameter. The range of viablity values by definition should be between 0 and 100. But the viabalities greater than 100 and lower than 0 are also accepted.
trunc	logical(1) A flag that identify if the viabality values should be truncated to be in the range of (0,100)
verbose	logical(1) If 'TRUE' the function will retrun warnings and other infomrative messages.

Value

Returns the normalized linear slope of the drug response curve

Examples

dose <- c(0.0025,0.008,0.025,0.08,0.25,0.8,2.53,8)
viability <- c(108.67,111,102.16,100.27,90,87,74,57)
computeSlope(dose, viability)

bhklab/PharmacoGx documentation built on April 18, 2024, 3:13 a.m.