Description Usage Arguments Details Value
It suggests a LOD Score for declaring statistical significance for two-point tests for linkage between all pairs of markers, considering that multiple tests are being performed.
1 | suggest.lod(x)
|
x |
an object of class |
In a somehow naive approach, the function calculates the number of two-point tests that will be performed for all markers in the data set, and then using this to calculate the global alpha required to control type I error using Bonferroni's correction.
From this global alpha, the corresponding quantile from the chi-square distribution is taken and then converted to LOD Score.
This can be seen as just an initial approximation to help users to select a LOD Score for two point tests.
the suggested LOD to be used for testing linkage
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