initial.guess.alpha: Calculate initial alpha values (labeled RNA) by closed form...

In carinademel/RNAlife: Quantifying kinetic parameters to determine the RNA life cycle

Description

Calculate initial alpha values (labeled RNA) by closed form solution

Usage

initial.guess.alpha(N = 1, L, counts, gene.names = rownames(counts),
  seq.depths, cross.cont, labeled.samples,
  total.samples = c(1:length(seq.depths)[-labeled.samples]))

Arguments

N	number of cells
L	length of genes
counts	count table for genes (rows) and samples (columns)
gene.names	names of features == rownames of count table for which the initial guess should be calculated
seq.depths	vector with sequencing depths for each sample
cross.cont	vector with cross contamination rates for each sample
labeled.samples	numeric vector indicating which of the samples are labeled RNA
total.samples	numeric vector indicating which of the samples are total RNA

Value

initial guess for alpha for given genes

Author(s)

Carina Demel

carinademel/RNAlife documentation built on May 13, 2019, 12:43 p.m.