characterizeMarkerThresholds: Characterize Marker Thresholds

Description Usage Arguments Value

Description

Construct a matrix of clusters with marker genes captured with ranges of effect size and cluster hit threshold values. The resulting matrix should help at selecting optimal threshold values.

Usage

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characterizeMarkerThresholds(FGDEGtab, esThresh = seq(0.5, 1, 0.01),
  nThresh = NULL, clusterColumn = "cluster_id",
  geneColumn = "entrez_id", effectColumn = "effect.size")

Arguments

FGDEGtab

The raw FASTGenomics Differentially Expressed Gene table, e.g. the output from FASTGenomics calc_de_genes_nonparametric.

esThresh

A vector of minimal effect sizes; defaults to seq(0.5, 1, .01).

nThresh

An optional vector of maximum cluster numbers that contain a potential marker gene; defaults to NULL, which takes the range between 1 and the maximum number of clusters found in the FGDGEtab.

clusterColumn

Column name for cluster assignment; defaults to "cluster_id".

geneColumn

Column name for gene ID; defaults to "entrez_id".

effectColumn

Column name for effect size; defaults to "effect.size".

Value

The marker threshold matrix.


clajusch/ClEvaR documentation built on May 9, 2019, 4:55 a.m.