RTNsurvival is a tool for integrating regulons generated by the RTN package with survival information. For a given regulon, the 2tailed GSEA approach computes a differential Enrichment Score (dES) for each individual sample, and the dES distribution of all samples is then used to assess the survival statistics for the cohort. There are two main survival analysis workflows: a Cox Proportional Hazards approach used to model regulons as predictors of survival time, and a KaplanMeier analysis assessing the stratification of a cohort based on the regulon activity. All plots can be finetuned to the user's specifications.
Package details 


Author  Clarice S. Groeneveld, Vinicius S. Chagas, Mauro A. A. Castro 
Bioconductor views  GeneRegulation GeneSetEnrichment GraphAndNetwork NetworkEnrichment NetworkInference Survival 
Maintainer  Clarice Groeneveld <clari.groeneveld@gmail.com>, Mauro A. A. Castro <mauro.a.castro@gmail.com> 
License  Artistic2.0 
Version  1.7.3 
Package repository  View on GitHub 
Installation 
Install the latest version of this package by entering the following in R:

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