summix_calc: summix_calc

In hendriau/Summix: Summix2: A suite of methods to estimate, adjust, and leverage substructure in genetic summary data

summix_calc

Description

Helper function for estimating mixture proportions of reference groups from large (N SNPs>10,000) genetic AF data, using slsqp to solve for least square difference

Usage

summix_calc(data, reference, observed, pi.start = NA)

Arguments

data	A dataframe of the observed and reference allele frequencies for N genetic variants. See data formatting document at https://github.com/hendriau/Summix for more information.
reference	A character vector of the column names for the reference groups.
observed	A character value that is the column name for the observed group.
pi.start	Length K numeric vector of the starting guess for the reference group proportions. If not specified, this defaults to 1/K where K is the number of reference groups.

Value

data frame with the following columns

objective: least square value at solution

iterations: number of iterations for SLSQP algorithm

time: time in seconds of SLSQP algorithm

filtered: number of SNPs not used in estimation due to missing values

K columns of mixture proportions of reference groups input into the function

hendriau/Summix documentation built on Nov. 13, 2024, 6:53 a.m.