Haploid_regulators: Haploid mutagenesis screens for regulators of protein...

In hfang-bristol/XGR: Exploring Genomic Relations for Enhanced Interpretation Through Enrichment, Similarity, Network and Annotation Analysis

Haploid mutagenesis screens for regulators of protein phenotypes

Description

This dataset contains regulators of 11 protein phenotypes identified by haploid mutagenesis screens.

Usage

data(Haploid_regulators)

Value

a data frame. It has the following columns: "Gene" (gene symbol; regulators), "MI" (mutation index; negative values for positive regulators and positive values for negative regulators), "FDR" and "Phenotype" (one of 11 protein phenotypes).

References

Brockmann et al. (2017). Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature, 546:307-11.
Mezzadra et al. (2017). Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature, 549:106-10.

Examples

## Not run: 
Haploid_regulators <- xRDataLoader('Haploid_regulators')
Haploid_regulators[1:5,]
## for 'PDL1'
ind <- grepl('PDL1', Haploid_regulators$Phenotype)
df <- Haploid_regulators[ind,c('Gene','MI','FDR')]

## End(Not run)

hfang-bristol/XGR documentation built on Feb. 4, 2023, 7:05 a.m.