README.md

In jgockley62/igraphNetworkExpansion: Trace Subnetworks from an AD Necortical Network of Protein-Protein Interactions

Pathway Tracing Package

Compute Environment and Sandbox Infrastructure

Establishing linked docker containers with an RStudio Sandbox environment and a linux VIM hosted cytoscape application is supported in separate repository. This can be leveraged on and AWS EC2 instance using docker-compose. https://github.com/jgockley62/networktracing

Installation

remotes::install_github("jgockley62/igraphNetworkExpansion")

Building a template tetwork

Tracing a template network

The set of functions currently imports 2 gene lists, a targets list and a sentinel list. Tracing paths within the template network occurs pairwise within the targets list and pairwise between each target and each sentinel. Tracing is currently not preformed pairwise from sentinel to sentinel.

• Tracing: The igraph tracing method currently employed is igraph::get.all.shortest.paths().

• Cutoff Limit: The path cutoff limit is currently defined from the whichever is greater between the median and mean of traces resulting from the target gene to the sentinel genes. If there are no trace paths in this object the target gene to other target genes trace object is used.

jgockley62/igraphNetworkExpansion documentation built on April 15, 2022, 12:14 a.m.