ABselectMM: Run model with selection against spontaneous gain of...

In jlab-code/AlphaBeta: Computational inference of epimutation rates and spectra from high-throughput DNA methylation data in plants

Run model with selection against spontaneous gain of methylation (ABselectMM)

Description

This model assumes that heritable losses of cytosine methylation are under negative selection.

Usage

ABselectMM(pedigree.data, p0uu, eqp, eqp.weight, Nstarts, out.dir, out.name)

Arguments

pedigree.data	pedigree data.
p0uu	initial proportion of unmethylated cytosines.
eqp	equilibrium proportion of unmethylated cytosines.
eqp.weight	nweight assigned to equilibrium function.
Nstarts	iterations for non linear LSQ optimization.
out.dir	output directory.
out.name	output file name.

Value

ABselectMM RData file.

Examples

#Get some toy data
inFile <- readRDS(system.file("extdata/dm/","output.rds", package="AlphaBeta"))
pedigree <- inFile$Pdata
p0uu_in <- inFile$tmpp0
eqp.weight <- 1
Nstarts <- 2
out.name <- "CG_global_estimates_ABselectMM"
out <- ABselectMM(pedigree.data = pedigree,
                  p0uu=p0uu_in,
                  eqp=p0uu_in,
                  eqp.weight=eqp.weight,
                  Nstarts=Nstarts,
                  out.dir=getwd(),
                  out.name=out.name)

summary(out)

jlab-code/AlphaBeta documentation built on April 23, 2022, 11:02 a.m.