MethylResolver: MethylResolver algorithm

In jysonganan/methylDeConv: Computational pipeline for deconvolution of methylation data.

MethylResolver algorithm

Description

MethylResolver deconvolution algorithm

Usage

MethylResolver(
  methylMix,
  methylSig,
  probes_select,
  alpha = seq(0.5, 0.9, by = 0.05)
)

Arguments

methylMix	Beta value matrix of methylation array for mixture samples.
methylSig	Average reference profiles over each cell type.
probes_select	Probes selected.
alpha	Tuning parameters. Default range 0.5–0.9, which corresponds to fitting a trimmed least square regression to 50–90%, of the cpgs. Get the best alpha value based on RMSE between original and reconstructed mixture, and select best alpha for each mixture sample separately

Value

The matrix of deconvolution results with rows as mixture samples and columns as cell types.

jysonganan/methylDeConv documentation built on Aug. 8, 2022, 6:25 a.m.